Endocrine pancreas

Question 1

5 endocrine substances secreted by the Islets of Langerhans

Answer 1

Insulin (beta-cells)
Amylin (beta-cells, co-secreted with insulin)
Glucagon (alpha-cells)
Somatostatin (delta-cells)
Pancreatic polypeptide (PP-cells)

Question 2

Two phases pf glucose homeostasis

Answer 2

Absorptive phase
Post-absorptive phase

Question 3

Three main effects of insulin deficiency (and increase in glucagon)

Answer 3

-Decreased glucose uptake, increased gluconeogenesis
-Increased protein catabolism
-Increased lipolysis

Question 4

Consequences of decreased glucose uptake and increased gluconeogenesis

Answer 4

-Hyperglycemia
-Glucosuria
-Polydipsia
-Polyphagia

Question 5

Consequences of increased protein catabolism

Answer 5

-Increased circulating amino acids
-Weakness
-Weight loss
-Poor wound healing

Question 6

Consequences of increased lipolysis

Answer 6

-Increased NEFA
-Ketone body production
-Hepatic stenosis
-Hyperlipidemia
-Weight loss

Question 7

What is insulinoma?

Answer 7

Rare endocrine disorder in dogs and cats

Functional tumors in beta-cells
Continuous insulin production –> hypoglycemia