Endocrine HTN/Hypoglycemia (pathophys) Flashcards

1
Q

HTN symptoms

A

Usually silent

Headache, blurred vision when symptomatic

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2
Q

Hypokalemia symptoms

A

Muscle weakness, cramping

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3
Q

3 major endocrine causes of HTN

A
  1. Hyperaldosteronism
  2. Pheochromocytoma
  3. Cushing’s syndrome
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4
Q

All pt’s with cushings syndrome likely to be what

A

Obese

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5
Q

What do you need to measure to check for hyperaldosteronism? Why

A

Renin and aldosterone levels

Need both to dx primary vs secondary (low renin indicates primary via feedback inhibition)

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6
Q

What does saline do in normal pt’s vs hyperaldosterone pt’s

A

Will lower aldosterone in healthy patients (inc. volume status)
Wont lower in hyperaldosteronism

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7
Q

2 major causes of hyperaldosteronism

A
  1. Pituitary adenoma

2. Bilateral adrenal hyperplasia

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8
Q

Triad of pheochromocytoma symptoms

A

Sweating, Headaches, palpitations

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9
Q

what will 24 hour urine catecholamine test show in pheochromocytoma patients

A

Elevated corticoids and elevated epi

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10
Q

Who doesn’t normally get hypoglycemia

A

Untreated diabetic patients and non-diabetics

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11
Q

Hypoglycemia is almost always caused by?

A

Treatment in diabetics

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12
Q

Causes of hypoglycemia in non-diabetic patients

A
  1. Severe organ failure (liver, kidney, sepsis)
  2. Insulinomas
  3. Factitious (intentional)
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13
Q

What blood sugar defines hypoglycemia

A

Less than 70

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14
Q

What determines severe hypoglycemia

A

When pt’s need help (i.e can’t correct blood sugar themselves)

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15
Q

What is pseudohypoglycemia

A

Symptoms of hypoglycemia with normal blood sugar

Usually from rebound of pt’s who recently had hypoglycemic episode

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16
Q

Major causes of hypoglycemic related death

A
  1. Increased QT intervals (poss acquired long QT syndrome)

2. Activates pro inflammatory mechanisms

17
Q

Most common cause of hypoglycemia in diabetics? other causes?

A

Unusual exercise

Also missed meals and alcohol abuse (impairs liver gluconeogenesis)

18
Q

What does recurrent hypoglycemia cause

A

Syndrome of impaired response to hypoglycemia

Will have impairment of epi release