Endocrine and Reproductive Physiology Q Flashcards
Which receptor resides in the cytoplasm in the absence of hormone?
a. Insulin receptor
b. Thyroid hormone receptor
c. prolactin receptor
d. Glucocorticoid receptor
D
One general mode of an intracellular signaling pathway involves:
a. exocytosis of matrix molecules
b. protein synthesis of a hormone receptor
c. covalent phosphorylation of protein or lipids
d. replication of DNA
C
GPCRs function as:
a. ligand-activated tyrosine kinases
b. Ligand-activated GEFs
c. Ligand-activated phosphatases
d. Ligand-activated phospholipases
B.
GPCRs can be down-regulated by:
a. Ligand-induced enodyctosis
b. Transphosphorylation on tyrosine residues
c. Dimerization within the cell membrane
d. Activation of Gs subunit
a
The transcription factors called STATs are activated by which class of receptor?
a. receptor tyrosine kinase
b. steroid hormone receptor
c. GPCR
d. Cytokine receptor
D
Which of the following is true concerning coactivator proteins?
A. they relax chromatin coiling
B. they reside in the cytoplasm
C. They repress gene transcription
D. They directly bind to steroid hormones
A
During the gastric phase, gastrin secretion is stimulated primarily by:
a. Histamine
b. Long chain FA
c. Somatostatin
d. Peptides
D
Erythromycin can be used to treat delayed gastric emptying through acting as an agonist for:
a. somatostatin
b. motilin
c. CCK
d. GLP-1
B
The term incretin is used to describe a hormone that;
a. sensitizes G cells to stomach distension
b. sensitizes intestinal K cells to long chain FA
c. Sensitizes pancreatic B cells to glucose
d. Sensitizes intestional L cells to glucose
C
- A 25 yo patient was found to have abnormal overnight fasting blood values during a yearly physical exam. Genetic testing revealed the presence of a partial loss-of-function mutation in the GLUT2 gene. The finding from the initial blood work that ultimately pointed to GLUT2 was:
a. elevated liver enzymes
b. low cortisol
c. elevated LDL
d. elevated glucose
D
- during acute hypoglycemia, insulin secretion in inhibited by low glucose and:
a. cholinergic singaling through the muscarinic recpetor
b. chatecholamine signaling through the a2 adrenergic receptor
c. glucagon signaling through the glucagon receptor
d. GLP-1 signaling through the GLP-1 receptor
B
