Endocrine Flashcards
Toxic Thyroid Adenoma
The hyperplastic thyroid cells autonomously produce thyroid hormone without TSH
Neonatal thyrotoxicosis
Got it from her mama (Graves Dz)
Transplacental anti-TSHr Ab
Self-resolves in 3 months (when maternal Ab is gone)
In the meantime, give methimazole & beta blocker
PTH-Independent Hypercalcemia
Malignancy
Vitamin D Toxicity
Extrarenal conversion of 25-hydroxyVitD to 1,25 (Sarcoid)
PTH-Dependent Hypercalcemia
Primary Hyperparathyroidism
Familial Hypocalicuric Hypercalcemia
Lithium
Why do Addison’s patients get hyperpigmentation?
Cosecretion of Melanocyte-stimulating hormone with ACTH
Why do Addison’s patients get vitiligo?
Autoimmune destruction of melanocytes
Hyponatremia in endocrine patient
Addison’s
Pubertal gynecomastia treatment
Reassurance
Resolves in most patients within a few months to 2 years
Werdnig-Hoffman Syndrome
AR Disorder
Degeneration of anterior horn cells & cranial nerve motor nuclei. Floppy Baby (but not botulism)
Baby appears normal at first
Weeks later, develops: Apathy Weakness Hypotonia Large tongue Umbilical hernia
Congenital hypothyroidism
Familial or sporadic
Most commonly thyroid dysgenesis (Aplasia, hypoplasia or ectopic gland)
Elderly patient has severe thyrotoxicosis
Before radioactive iodine, what do you give them?
Methimazole or PTU
Essentially debulk, since radioactive iodine will transiently worsen the hyperthyroidism
Main substrates for gluconeogenesis
Gluconeogenic amino acids (from breakdown of muscle)
Main ones: Alanine & Glutamine
Lactate (from anaerobic glycolysis)
Glycerol 3-phosphate (from triacylglycerol in adipose)
Precocious puberty
Development of secondary sex characteristics before the age of:
8 in girls
9 in boys
Central precocious puberty
FSH is high
LH is high
GnRH is activated
Peripheral precocious puberty
FSH is low
LH is low
Gonads or adrenals release excess sex hormones
Clinical features of PCOS
Oligo-ovulation
Clinical or biochemical hyperandrogenemia
Polycystic ovaries on imaging
No evidence of another diagnosis
Clinical features of nonclassic CAH (21-hydroxylase Deficiency)
Oligo-ovulation
Hyperandrogenemia
Increased 17-hydroxyprogesterone levels
Presents later than infancy (nonclassic)
Teens to twenties
Girls:
Acne
Irregular menses
Hirsutism
Boys:
Precocious puberty
Clinical features of Ovarian/Adrenal tumors
Older age
Rapidly progressive symptoms
Increased androgen levels (>3x normal level)
Hyperprolactinemia
Amenorrhea
Galactorrhea
Increased prolactin levels
Cushing Syndrome
Cushingoid features (moon facies, buffalo hump)
Nonsuppressible dexamethasone suppression test
Increasd 24h urinary free cortisol
Acromegaly
Excessive growth
Increased GH
Increased IGF-1
Pathophys of 21-hydroxylase deficiency
Neither cortisol nor aldosterone are made
Pituitary increases ACTH to rectify low levels of cortisol
Adrenals undergo hyperplasia
Build-up of 17-hydroxyprogesterone is diverted to androgen synthesis
Meanwhile, aldosterone deficiency causes salt wasting, though hyponatremia is variable
Additionally, androgen excess impairs hypothalamic sensitivity to progesterone
Rapid GNrH secretion
Hypersecretion of LH & FSH
Increased gonadal steroid production
Most common thyroid epithelial malignancy
Papillary Thyroid Cancer
Second place is Follicular Thyroid Cancer
Follicular Thyroid Cancer
Peak incidence age 40 - 60
Firm thyroid nodule (Cold on scintigraphy)
Often discovered incidentally