Bear the Children Flashcards
What can cause a false VDRL positive?
Antiphospholipid Antibody Syndrome
Young pregnant patient with previous miscarriages, positive VDRL & negative FTA-ABS
Previous miscarriages make you think Lupus
Negative FTA-ABS makes syphilis much less likely
The VDRL positive could be from Antiphospholipid
Common findings include clots, thrombocytopenia & prolonged aPTT.
Start on LMWH to reduce risk to current pregnancy
Timeline of Postpartum Blues
Onset of 2 - 3 days postpartum
Resolves within 2 weeks
Treatment: Reassurance
Timeline of Postpartum Depression
Onset typically 4 - 6 weeks postpartum (but can start anytime within the first year)
Lasts longer than 2 weeks
Treat with SSRIs and/or psychotherapy
Which SSRI is preferred in postpartum depression?
Sertraline (infant serum levels are undetectable, even with breastfeeding)
Hyperandrogenism during pregnancy is caused by
Ovarian masses
Luteoma
Theca Luteum Cyst
Krukenberg Tumor
African American pregnant patient with new-onset hirsutism & acne
Luteoma
Yellow or yellow-brown mass (often with areas of hemorrhage) of large lutein cells
Appears as solid ovarian mass (bilateral in half patients)
Benign
Puts female fetus at high risk of virilization
Treatment of Luteoma
Clinical monitoring (w/ ultrasound) Mass effect (hydronephrosis, obstructive labor, ovarian torsion) rare but nonzero risk. Surgery if so. Symptoms regress spontaneously after delivery
New onset solid ovarian mass in pregnancy
Luteoma
OR
Krukenberg Tumor
Krukenberg Tumor
Metastasis from primary GI cancer
Should present with other oncologic symptoms (weight loss, abdominal pain, etc)
Solid ovarian mass on ultrasound
Presents with hyperandrogenism
Female fetus at high risk of virilization
Biopsy & surgery indicated if malignancy is suspected
New onset multi-sepatated ovarian mass in pregnancy
Theca Lutein Cyst
Can be asymptomatic or cause hyperandrogenism (less likely)
Arises from high beta-hCG levels (molar or multip)
If complete hydatidiform mole, suction curettage
Theca Lutein Cyst will regress spontaneously
On TVUS:
Central heterogeneous mass
Numerous discrete anechoic spaces
Complete Hydatidiform Mole
Hyperemesis gravidarum
Bilaterally enlarged ovaries
Concerning for complete hydatidiform mole
How does a complete hydatidiform mole form?
Abnormal fertilization of empty ovum by 2 sperm
OR
Fertilization by 1 sperm that duplicates its genome
Leads to crazy high beta-hCG
Leads to hyperstimulation of ovaries and Theca Lutein Cysts
Main risk side effect of epidural anesthesia
Hypotension (occurs in 10% of epidurals)
Sympathetic nerves responsible for vascular tone are blocked
Vasodilation ensues, which can lead to venous pooling & hypotension
Complication can be fetal acidosis from hypoperfusion
Prevent with aggressive IV fluid volume expansion beforehand
Treat by placing mom on her Left side, give IV fluids and/or pressors
Rare side effect of epidural anesthesia in a high spinal or a total spinal
Depression of cervical spinal cord & brainstem activity
First signs:
Hypotension
Bradycardia
Respiratory difficulty
Late signs:
Diaphragmatic paralysis
Cardiopulmonary arrest
Pregnant patient receives epidural during delivery
Develops postural headache postpartum (worse sitting up, better lying down)
Dura was inadvertently punctured (“wet tap”)
Spinal fluid is leaking out
Definition of PPROM
Rupture of membranes < 37w
Some patients experience gush
Others experience intermittent leakage
Nitrazine-Positive
It is amniotic fluid, not urine
PPROM at >= 34w
Deliver
M&M associated with premature delivery decreases at 34w
Chorioamnionitis is bad news
Give intrapartum IV Penicillin if GBS status is unknown
PPROM at < 34w w/ signs of infection (maternal fever, fetal tachycardia) or fetal compromise
Deliver
First line therapy for stress incontinence in pregnancy
Kegels
Pessary
Elevated Maternal Serum AFP at 15 - 20 weeks
Open neural tube defects:
Anencephaly
Open spina bifida
Ventral wall defects:
Omphalocele
Gastroschisis
Multiple gestation
Rare:
Fetal congenital nephrosis
Benign obstructive uropathy
Decreased Maternal Serum AFP at 15 - 20 weeks
Aneuploidies:
Trisomy 18
Trisomy 21
Diagnosis of CF
Genetic testing of parents
If both parents are carriers:
CVS, Amniocentesis or fetal blood sampling can confirm
AFP is not affected
Maternal causes of elevated AFP
Hepatocellular Carcinoma
Gonadal Tumors
Liver Disease (Acute or chronic viral hepatitis)
Only suspect these if mom is symptomatic
What causes Trisomy 18?
Meiotic Nondisjunction (usually)
What causes Trisomy 21?
Meiotic Nondisjunction or Robertsonian Translocation
Low Maternal Serum AFP
Low estriol
High beta-hCG
High Inhibin A
Trisomy 21
Down Syndrome
Low Maternal Serum AFP
Very Low Estriol
Very Low beta-hCG
Normal Inhibin A
Trisomy 18
Asymmetric Moro Reflex
Pain with passive motion of affected extremity
Crepitus over affected clavicle
Displaced clavicular fracture
Heals spontaneously in 7 - 10 days w/o sequelae
Treatment = reassurance & guidance on gentle handling
Pinning infant’s sleeve to shirt can reduce motion and decrease pain
Why do we avoid Aspirin in infants?
To avoid Reye syndrome
Nonblanching blue-grey patches
Mongolian Spots
Benign, common in dark-skinned infants
Routine Prenatal Labs - Initial Visit
Rh (D) type, Ab screen H&H / MCV HIV, VDRL/RPR, HbSAg Rubella & Varicella Titers Pap (if screening indicated) Chlamydia PCR UCx Urine Protein
HbA1C or OGTT if mom is at risk for undiagnosed DMII
Routine Prenatal Labs - 24 - 28 weeks
H&H
Ab Screen (if Rh Neg)
50g 1h GCT
Repeat HbSAg & Chlamydia PCR if mom is high risk (IVDU, STIs earlier in pregnancy)
Routine Prenatal labs - 35 - 37 weeks
GBS Cx
Risk factors for gestational diabetes
Obesity
Excessive weight gain during pregnancy
Family history of DM
Previous macrosomic infant
When do we give Rhogam?
28 - 32w normal gestation <72h after delivery of Rh+ infant <72h after Spontaneous Abortion Ectopic pregnancy Threatened abortion Hydatidiform mole CVS, Amniocentesis Abdominal trauma 2nd & 3rd trimester bleeding External cephalic version
Any occasion for mom to be exposed to fetal blood
Rh(-) mom is sensitized and has elevated Ab titers already. Do we give Rhogam anyway?
No. Just monitor fetus closely for hemolytic disease.
Potential maternal complication of fetal demise
Coagulopathy after several weeks of fetal retention
Fetal ASD in AMA mom is associated with
Trisomy 21
Symmetric fetal growth restriction occurs when?
First trimester
Due to aneuploidy, congenital abnormalities or infection
Asymmetric fetal growth restriction occurs when?
Second & third trimesters
Due to maternal conditions leading to placental insufficiency, such as hypertension
Patient with placenta previa is at risk for
Painless but severe antepartum hemorrhage
Guidelines for managing placenta previa
May resolve on its own as lower uterine segment grows
Pelvic rest & abstinence from intercourse are recommended.
Clinicians should refrain from digital examination of the cervix
Vaginal delivery is contraindicated
Cesarean delivery is scheduled for 36 - 37 weeks to avoid exposing patient to labor contractions
Indications for cerclage
History of second-trimester deliveries Short cervix (<2.5cm)
If placenta previa resolves on its own, what is the patient still at risk for?
Vasa previa
Evaluate with doppler (weekly is not necessary)
Risk factors for postpartum urinary retention
Nulliparity Prolonged labor Instrumental delivery Regional anesthesia (reduces sensory & motor impulses from sacral spinal cord, leads to bladder atony) Perineal trauma (pudendal nerve palsy & perineal edema can lead to urinary retention)
When to suspect postpartum urinary retention
Patient is unable to void 6 hours after vaginal delivery
OR
Patient is unable to void 6 hours after removal of catheter for cesarean.
How to confirm postpartum urinary retention
Urethral catheterization more accurate than bladder scan
Confirms retention at >= 150mL urine
Treatment of postpartum urinary retention
Analgesia
Ambulation
If those don’t work, catheterize & reassure that retention is usually temporary and reversible
Postpartum decreased urine production
Postpartum hemorrhage can lead to renal hypoperfusion & ATN
OR
Preeclampsia can cause intense vasospasm & third spacing
Breast Engorgement
Onset 3 - 5 days postpartum
Occurs any time there is milk accumulating
Bilateral symmetric breast fullness, tenderness, warmth
No fever
Treatment of breast engorgement
Cold compresses
Acetaminophen
NSAIDS
Regular breastfeeding or pumping
Risk factors for abruptio placentae
Hypertension
Cocaine use
Maternal trauma
Abdominal and/or back pain late in pregnancy
Category 2 or 3 tracing
Vaginal bleeding
Abruptio placentae
May present with firm uterus, uterine distension (if bleeding is concealed) and low-amplitude frequent contractions
How often should BPPs be performed in gestational hypertension?
Weekly
BPP reveals 6/10
Equivocal
Repeat in 24 hours
Definition of Small for Gestational Age
Weight < 10th percentile for gestational age
Maternal factors leading to SGA infants
Preeclampsia Malnutrition Placental Insufficiency Multiparity Drug Use
Fetal factors leading to SGA infants
Genetic Factors
Chromosomal Abnormalities
Congenital Infections
Inborn Errors of Metabolism
SGA infants are at risk for
Hypoxia Perinatal Asphyxia Meconium Aspiration Hypothermia Hypoglycemia Hypocalcemia Polycythemia (a response to hypoxia)
When is it classified as Gestational Hypertension?
> =140 / >= 90 on 2 separate measurements at least 4h apart
New at >= 20w gestation (anything earlier is chronic)
AND
Proteinuria OR signs of end organ damage
Maternal pregnancy risks from hypertension
Superimposed Preeclampsia Postpartum Hemorrhage Gestational Diabetes Abruptio Placentae Cesarean Delivery
Fetal risks from maternal hypertension
Fetal growth restriction
Perinatal mortality
Preterm delviery
Oligohydramnios
Acute Fatty Liver of Pregnancy
Nausea
Vomiting
Abdominal Pain
Jaundice
In a patient with preeclampsia bordering on hypertensive emergency, what anithypertensives would you use?
IV Hydralazine
IV Labetalol (if patient is not bradycardic)
PO Nifedipine