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Phsyiology 210 B > Endocrine 2 > Flashcards

Endocrine 2 Flashcards

1
Q

Structure of thyroid gland

A
  • Active follicles
  • resting follicles
  • parafollicular / C-cells
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2
Q

What does the parafollicular cells secrete? Where these cells located ?

A

Secretes calcitonin. Located in thyroid gland.

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3
Q

Where’s the thyroid gland located?

A

In trachea

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4
Q

What does calcitonin do?

A

Regulates blood Ca+

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5
Q

Structure of follicles in the thyroid gland

A

Follicles composed of a single layer epithelial or follicular cells. Sender of follicle called colloid

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6
Q

Thyroid hormones

A

1) synthesizes from tyrosine and iodine

2) Intermediates:
- mono-iodotyrosine (MIT)
- di-iodotyrosine (DIT)

3) Active hormones
- tri-iodotyrosine (T3)
- Tetra-iodotyrosine (T4)

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7
Q

What are thyroid hormones synthesized from

A

Tyrosine

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8
Q

The “life story of the thyroid hormones

A

1) uptake of iodide from the blood (active transport)
2) synthesis of thyroglobulin (glycoproteins w tyrosine (TRH))
3) iodination of TRH = MIT and DIT (intermediates)
4) coupling of iodotyrosines = T3 and T4 (active forms)
5) storage in colloid (T4>T3)
6) endocytosis of colloid breakdown by lysosomal enzymes (recycle iodine +AA)
7) secretion of hormones into blood (T4>T3)
8) transport in blood, majority bound/inactive
9) T4 as a prohormone (most T4–>T3 in tissues, T3 is major hormone)
10) thyroid hormone receptors (present in cell nucleus; T3 binds more strongly)
11) half life —> T3=1 day / T4 = 7 days

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9
Q

Where are thyroid hormones stored?

A

In the colloid regions within the follicle cells

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10
Q

Which thyroid hormone is the major one

A

T3. T4 converts to become T3 eventually.

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11
Q

In storage, when thyroid hormones is greater in number

A

T4 > T3

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12
Q

When thyroid hormones are secreted into the blood, which one is greater in number

A

T4 > T3

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13
Q

Of T3 and T4, which one has a greater % bound/inactive?

A

T4

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14
Q

Thyroid follicular cell

A

1) iodine in the blood moved into the follicle via Na+/I- pump
2) iodine moved to luminal side and exits via pendrin transporter channel
3) peroxidase reacts iodine to form the intermediates of MIT and DIT
4) T3/T4 formed in a protein called thyroglobulin. Enter follicle to be stored in the colloid of the follicle
5) once needed, thyroglobulin releases T3, T4, and iodine.
6) T3 and T4 exit follicle out into the blood via endocytosis (active form). Iodine exits back to luminal side

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15
Q

Physiological actions of thyroid hormones

A

1) act on most tissues —> change translation and transcription
2) increase metabolism
3) necessary for growth and development

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16
Q

Actions of thyroid hormones
(T3 and T4)

1) Metabolism:

A

1) Metabolism:
- catabolism and anabolism INC
- INC base metabolic rate = INC O2 consumption = inc hear production
- INC carbohydrate absorption
- INC protein breakdown (muscle)
- INC fat breakdown
- INC fat breakdown
- INC cholesterol metabolism
- DEC blood cholesterol

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17
Q

Actions of thyroid hormones
(T3 and T4)

2) Growth and development:
3) other effects:

A

2) Growth and development:
- act as tissue Growth factors
- INC protein synthesis
- INC GH/IHF production
- CNS maturation in fetus

3) other effects:
- cardiovascular system (INC heart rate)
- potentiation of sympathetic nervous system (INC beta adrenergic receptors)
- reproductive system

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18
Q

Control of thyroid hormone secretion

A

Hypothalamus = TRH = ant pit = TSH = thyroid gland = Thyroid hormones T3 and T4

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19
Q

What kind of feedback system do thyroid hormones have, and on what

A

(-) feedback system on BOTH the hypothalamus and ant pit

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20
Q

Cold environments can influence the hypothalamus to increase TSH and TRH, increase thyroid hormone output which increase metabolic process =

A

increase heat.

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21
Q

Overactivity of thyroid hormones

A

Graves disorder: autoimmune disorder which stimulated thyroid gland.

  • increase in basometabolic rate
  • exophthalmos (bulging of eye)
  • goitre (neck swelling)
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22
Q

Underactivity of thyroid hormones

A

Hashimoto’s Thyroidits: Autoimmune disorder which destroys thyroid gland and blocks hormone synthesis.

  • Myxedema
  • goitre
  • cretinism in children
  • iodine deficiency
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23
Q

• Goitre =

A

enlargement of thyroid gland.

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24
Q

• Exophthalmos:

A

pertution of the eye balls (popping out)

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25
Q

Thyroid hormone mechanism

A

OVERACTIVTY: Normally follicular cell has receptor for TSH, but now body made antibodies for TSH receptors, these antibodies stimulate the recpetors tho. Causes overstimulation and excessive amount of thyroid hormone and all the effects will be very high.

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26
Q

Thyroid hormone under activity mechanism

A

UNDERACTIVITY: not producing Normal amount of hormones, so become hypothyroid. When hormone levels goes down, causes less negative feedback = more TRH and TSH that will stimulate the gland, causing goitre.

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27
Q

• Iodine deficiency

A

most common cause for lack of thyroid hormone, no good source of iodine in diet.

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28
Q

• Cretinism

A

abnormalities in brain development in children

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29
Q

• Mixedma =

A

swollen face / skin.

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30
Q

Distribution of Ca+ in the body

Extracellular VS intracellular

A

Extracellular (0.1%)
- Free Ca+ = 500mg
- Bound Ca+ = 500 mg
(50%:50%)

Intracellular (0.9%)

  • Free Ca+ = 0.1mg
  • Bound Ca+ = 10g
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31
Q

Importance of Ca+

A
  • structural role
  • intracellular messenger
  • intracellular messenger
  • regulation of excitability
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32
Q

Important of phosphate

A
  • structural role
  • metabolism (ATP)
  • buffering agent
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33
Q

Target for parathyroid hormone PTH, form parathyroid gland

A

Bone

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34
Q

Target for active vit D form kidneys

A

GIT

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35
Q

Target for Calcitonin from thyroid gland

A

Kidney

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36
Q

Bone structure

Calcified matrix

A

1) protein framework (osteoid), made of collagen.

2) Ca + Phosphate salts (hydroxyapatite)

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37
Q

Types of Bone cells

A

1) osteoblasts (bone forming)
2) osteoclasts (bone destroying)
3) osteocytes (long living, response to stress)

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38
Q

Location of parathyroid gland ?

A

Bottom of the neck

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39
Q

What is the function of PTH?

A

To increase the level of blood Ca+ and decrease level of blood phosphate

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40
Q

Which cells secrete PTH

A

Chief cells within the parathyroid

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41
Q

The role of PTH in osteocytic osteolysis

A

Maintains constant blood Ca+ levels

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42
Q

Which bone cells are on the surface of the bone, and which in inside the matrix ?

A
  • Osteoblasts and osteoclasts are on the surface.

- Osteocytes are inside the matrix, within the inner fluid space.

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43
Q

Osteocytes come from

A

Osteoblasts

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44
Q

Ca+ in the bone moves from within the

A

fluid filled inner matrix, out towards the surface

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45
Q

Most of the Ca+ in the bone is present in a

A

Non readily exchangeable form, but little bit is exchangeable near the surface of the bone.

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46
Q

What is the movement of Ca+ within the bone and bones cells

A

Ca+ moves from the fluid filled intraceullar matrix of the bone towards outside t the surface, Ca+ is the taken up by the osteocytes, moved through Ca+ channels in osteocytes, transfers Ca+ to the osteoblasts via tight junction, the its pumps out into the blood, under the influence of PTH

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47
Q

Osteoclasts reabsorption

A

Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in a transfer of calcium from bone tissue to the blood.

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48
Q

Osteoclasts have one or multiple nuclei?

A

Multiple

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49
Q

Steps for osteolytic reabsorption

A

1) osteoclasts form attachments to bone surface, and create closed off space.
2) osteocytes secrete H+ and enzymes = eat away at bone = releasing Ca+, collagen, and phosphate into the blood.
3) osteoblasts move inot the eaten away space and secrete osteoid material = fills in hole.
4) osteoid traps the osteocytes, Ca+, phosphate all inside the mixture.

50
Q

Actions of PTH

A
  • Increases blood Ca+ and decreases blood phosphate.
  • Bone is storage site of Ca and phosphate, under PTH, both move into the blood.
  • PTH act on small intestine to absorbs into the blood.
  • Both Ca and phosphate filtered in kidney, but under PTH, Ca+ is reabsobed, but phosphate is excreted in urine.
51
Q

Control of PTH secretion

A

PTH regulated by blood level of Ca+

52
Q

Is PTH regulated by either hypothamus or ant pit?

A

NO

53
Q

What happened to PTH is Ca+ is

  • LOW
  • HIGH
A

LOW Ca+ = increase in PTH

HIGH Ca+ = decrease in PTH

54
Q

How does the chief cell regulate the release of PTH according to blood levels of Ca+??

A

Chief cells have Ca+ sensor receptors that detect blood Ca levels and producing PTH accordingly.

Ca+ receptor is G protein linked receptor.

  • Gi —> inhibitory G protein that decreases release of second messenger cAMP secretion = decrease in PTH
  • Gq —> excitatory G protein, increases second dmessneger IP3 and Ca+
    = decrease in PTH

So when Ca in blood to high, these both act to decrease PTH release.

55
Q

How do the G proteins (Gi and Gq) in the chief cell respond to high levels of Ca+ in blood

A

Gi = Decrease cAMP = decrease PTH

Gq = Increase IP3 and Ca++ = decrease PTH

56
Q

How do the G proteins (Gi and Gq) in the chief cell respond to low levels of Ca+ in blood

A

Gi = increase cAMP = increase PTH

Gq = decrease IP3 and Ca++ = increase PTH

57
Q

A decrease in Ca++ will cause PTH to

A

Increase

58
Q

Synthesis of active vit D

A

From (dehydrocholesterol) in SKIN + diet —> cholecalciferol (vit D3) —> LIVER (25-OH-cholecalciferol) ——> KIDNEY 1,25 (OH)2 cholecalciferol (calcitriol or Vit. D)

59
Q

What converts 25-OH cholecalciferol into VIT D or calcitriol ?

A

1 alpha hydroxylase which is increased by PTH in a (+) manner.

60
Q

What kind of hormon is vit D?

A

Steroid hormone

61
Q

In the liver, is vit D active or inactive

A

Inactive

62
Q

In the kidneys is vit D active or inactive?

A

Active

63
Q

active form of vit D (calcitonin) is produced, in the presence of enzyme

A

hydroxoxylase

64
Q

PTH stimulates the conversion of inactive Vit D to

A

active form, form the liver to the kidneys.

65
Q

Is pancreas endocrine or exocrine ?

A

Both .

  • Endocrine is ductless gland
  • Exocrine is duct cell+ acinar cells
66
Q

The endocrine part of the pancrease contains what kind of cells ?

A

islet of langerhans

67
Q

Pancreatic hormones (5X)

A
  • glucagon
  • insulin
  • somatostatin (SS)
  • pancreatic polypeptide (PP)
  • vasoactive intestinal polypeptide
68
Q

Types of islet of langerhans cells

A
  • Beta cell (make, store, and secrete hormones)

- alpha cells (fewer)

69
Q

The following are released by what kind of islet of langerhans cell?

  • glucagon
  • insulin
  • somatostatin (SS)
  • pancreatic polypeptide (PP)
  • vasoactive intestinal polypeptide
A
  • glucagon —-> ALPHA
  • insulin —-> BETA
  • somatostatin (SS) —-> DELTA
  • pancreatic polypeptide (PP)——> F or PP
  • vasoactive intestinal polypeptide -> DELTA
70
Q

• Diabetes mellitus is when your

A

pancreas doesn’t produce enough insulin to control the amount of glucose, or sugar, in your blood. Large vol of sweet urine (lots of sugar) made.

71
Q

• Diabetes insipidus:

A

Has nothing to do with the pancreases or with blood sugar.

It results in diluted fluid/urine produced in the absence of ADH. No ADH = no water reabsorption

72
Q

Insulin is the _____ hormone

Glucagon is the _______ hormone

A

Insulin is the feasting hormone

Glucagon is the fasting hormone

73
Q

Since insulin is the feasting hormone, in term of nutrient movement, it will

A
  • increase uptake of nutrient after large meal

- decrease passage of nutrient into the blood

74
Q

Since glucagon is the fasting hormone, in term of nutrient movement, it will

A
  • decrease uptake of nutrient after large meal

- increase passage of nutrient into the blood

75
Q

insulin influences the movement of blood slicker to different sites form the blood, What are the target sites

A
  • Muscle
  • adipose
  • liver
76
Q

What does insulin move from the blood to the muscle ?

A

Moved glucose (+) to become glycogen for storage, and amino acids (+) to become proteins

77
Q

What does insulin move from the blood to the adipose tissue ?

A

Moves glucose (+) and FA (+) to form triG (storage form).

78
Q

What does insulin move from the blood to the liver ?

A

Moves glucose to become glycogen (storage), Energy, and FA (FA go on to form triG). Also moved AA inot the liver to produce protein

79
Q

Is the uptake of glucose into the liver by the influence of insulin (+) or (-)?

A

Neither, Both the brain (hypothalamus) and the liver can take up glucose in the absence of insulin, cuz diff glucose transporters found in diff tissues.

Insulin then effects the end products after having a large meal.

80
Q

Actions of insulin summary (LIVER)

A
  • INC. glycogenesis (synthesis)
  • INC. glycolysis (formed from ATP
  • INC. fat synthesis
  • DEC. fat breakdown
  • INC. proteins synthesis
  • DEC. protein breakdown
  • DEC. glycogenolysis (breakdown)
  • DEC. gluconeogenisis (formed form carbohydrate source)
  • DEC. ketogenesis (form ketobodies form broken down fats)
81
Q

Actions of insulin summary (MUSCLE)

A
  • INC glucose uptake
  • INC glycogenesis
  • DEC glycogenolysis
  • INC amino acid uptake
  • INC protein synthesis
  • DEC protein breakdown
82
Q

Actions of insulin summary

ADIPOSE TISSUE

A
  • INC glucose uptake
  • INC glycolysis
  • INC FA uptake
  • INC fat synthesis
  • DEC fat breakdown
83
Q

Mechanism of insulin

A

Insulin hitting receptor in outer region, causes conformational changes which then cause activation of enzyme (tyrosine kinase) in the inner region of the receptor.

When tyrosine becomes active, causes changes in many molecules inside the cell, which are then glued together to form IRS (insulin receptor substrate).

84
Q

What does the IRS effect?

A
  • transport systems
  • enzyme activity
  • gene expression
85
Q

Transport of glucose mechanisms

A

1) Secondary Active Transport (uphill)
- SGLT1
- SGLT2

2) Facilitated transport (downhill)
- GLUT1
- GLUT2

86
Q

Which GLUT transporter is sensitive to insulin?

A

GLUT 4

87
Q

SGLT is a

A

Na+/glucose cotransporter

88
Q

GLUT is a

A

Glucose transporter

89
Q

Action of insulin: glucose uptake

  • if there’s no insulin
A

No action occurs as it uses GLUT 4 transporters, which re insulin dependant and require for it to be present to be activated

90
Q

Action of insulin: glucose uptake

  • if there’s plus insulin (no excercise)
A

Translocation of vesicle occurs.
- insulin binds to insulin recpetors = forms IRS = takes vesicle with glucose receptors on it to embed to the outside of the cell = all receptors on vesicle are not on the surfaces of the cell = increase the uptake of glucose !

91
Q

Where does glucose come from?

1) short term?
2) long term?
3) longer still ?

A

1) short term: glucose readily available after any meal.
2) long term lover glycogen stores are broken down
3) longer still “new” glucose made form non-carbohydrate sources, like amino acids (gluconeogensis)

92
Q

gluconeogensis

A

Production of glucose from non carbohydrate sources, like amino acids

93
Q

Main site of action of glucagon is the

A

Liver

94
Q

High insulin leads to

A

Hypoglycaemia

95
Q

High glucagon leads to

A

Hyperglycaemia

96
Q

Actions of insulin in LIVER

A 
Glycogenesis —> INC
Glycogenolysis  —> DEC
Glycolysis —>INC
Glyconeogenesis —>DEC
Lipogenesis —> INC
Lipolysis —> DEC
Ketogenesis —>DEC
Protein synthesis —>INC
Proteolysis —> DEC
97
Q

Actions of glucagon on the LIVER

A 
Glycogenesis —> DEC
Glycogenolysis  —> INC
Glycolysis —>DEC
Glyconeogenesis —>INC
Lipogenesis —> DEC
Lipolysis —> INC
Ketogenesis —>INC
98
Q

Other pancreatic hormones

A

1) amylin
2) somatostatin
3) pancreatic polypeptide
4) vasoactive intestinal polypeptide

99
Q

Amylin

A
  • secreted w insulin
  • decrease food intake
  • decrease rate of gastric emptying
  • decrease glucagon secretion
100
Q

Somatostatin

A
  • inhibiting release of insulin and glucagon
101
Q

Pancreatic polypeptide

A
  • decrease pancreatic enzyme secretion

- inhibit gallbladder contraction

102
Q

Vasoactive intestinal polypeptide

A
  • increase pancreatic water secretion= diarrhea
103
Q

Glucose sensing

A

Glucose enters via GLUT2 ( NOT influenced by insulin) = Metabolized glucose increases the ratio of ADP:ATP = K+ channels close (atp sensitive), = K+ inside the cell increases = depolarization of outer membrane = opening of voltage gated Ca+ Channels = more Ca+ inside the cell = Insulin stored in the granules then is released by Ca+

—> Insulin then lowered blood glucose by taking it into the cell. The opposit effect is true. Low glucose = more insulin goes into the cell.

104
Q

Why is glucagon secretion increased by amino acids?

1) carbohydrate-rich meal
—> increase blood glucose

A

Increase blood glucose (effects insulin and glucagon separately) ——>

  • Increase insulin = Decrease blood glucose
  • Decrease glucagon - Decrease blood glucose

blood glucose levels have been restored back to normal*

105
Q

Why is glucagon secretion increased by amino acids?

1) protein-rich meal
—-> Increase amino acids in blood

A

Increase amino acids in blood (effects insulin and glucagon separate) —>

  • Increases insulin = Decrease blood glucose
  • Increase glucagon = Increase blood glucose

blood glucose remains +/- constant after protein rich meal cuz they cancel each other out

106
Q

Role of nutrients in blood:

  • Increased level of glucose
  • Increased levels of some amino acids

Secretion of insulin is:

A
  • Increased level of glucose = Increased

- Increased levels of some amino acids = Increased

107
Q

Role of nutrients in blood:

  • Increased level of glucose
  • Increased levels of some amino acids

Secretion of glucagon is:

A
  • Increased level of glucose = Decreased

- Increased levels of some amino acids = Increased

108
Q
  1. Role of hormones from GIT:

(“incretins”). eg GLP-1, GIP, CCK, secretin…

Secretion of insulin is

A

(“incretins”). eg GLP-1, GIP, CCK, secretin… = Increased

109
Q
  1. Role of hormones from GIT:

(“incretins”). eg GLP-1, GIP, CCK, secretin…

Secretion of Glucagon is

A

(“incretins”). eg GLP-1, GIP, CCK, secretin… = depends on which incretin

110
Q
  1. Role of local islet hormones:
  • Somatostatin
  • Insulin
  • Glucagon

Secretion of insulin will:

A
  • Somatostatin = decreased
  • Insulin = X
  • Glucagon = increased
111
Q
  1. Role of local islet hormones:
  • Somatostatin
  • Insulin
  • Glucagon

Secretion of glucagon will:

A
  • Somatostatin = decreased
  • Insulin = decreased
  • Glucagon =. X
112
Q
  1. Role of nerves:
  • Parasympathetic (ACh)
  • Sympathetic

Secretion of insulin will:

A
  • Parasympathetic (ACh) = increased

* Sympathetic. = deadens on type of receptor)

113
Q
  1. Role of nerves:
  • Parasympathetic (ACh)
  • Sympathetic

Secretion of glucagon will:

A
  • Parasympathetic (ACh) = X

* Sympathetic. = increased

114
Q

Too much insulin causes:

A
  • insulin securing tumour

- insulin overdose

115
Q

Consequences of too much insulin

A
  • lower blood glucose levels (hypoglycaemia)
  • feel hungry
    brain requires glucose:
  • inc sympathetic activity (sweating)
  • inc production in glucagon and adrenaline
116
Q

Diabetes mellitus TYPE 1:

A
  • autoimmune disease
  • beta cells destroyed
  • insulin deficient
  • mainly in young ppl
  • 5-10% of all DM cases
117
Q

Diabetes mellitus TYPE 2:

A
  • increased resistance to insulin
  • initial increase in insulin secretion
  • relative insulin deficient (linked to obesity)
  • more in adults
  • 90-95% of all DM cases
118
Q

Problems with diabetes mellitus

A
  • low blood glucose levels (hyperglycemia)

- tissues are starving

119
Q

Effect of diabetes mellitus to insulin dependant tissue

A

Glucose uptake will decrease if insulin is deficient for tissues that are insulin dependant.

120
Q

Effect of diabetes mellitus to insulin independent tissue

A

Glucose uptake will increase if insulin is deficient for tissues that are insulin independent (move down conc gradient)

121
Q

Diabetes mellitus TYPE 1 treatments

Inability to produce insulin

A
  • inject insulin
  • pancreatic transplant
  • islet cell transplant
  • gene therapy
  • increase growth of new islet cells
122
Q

Diabetes mellitus TYPE 2 treatments

Increased resistance to insulin

A
  • dietary control and excersice

- drugs that’s increase insulin secretion and or response to insulin

Phsyiology 210 B (24 decks)

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