Endocrine Flashcards
exam 3
which system is faster the endocrine or nervous?
Nervous system is faster due to use of action potentials and neurotransmitters
Endocrine Glands include
Pituitary
Thyroid
Parathyroid
Adrenal
Pineal
ograns/tissues with endocrine cells
hypothalamus
thymus
pancrease
ovaries/testes
kidneys,liver,stomach, SI, Heart, skin, Adipose tissue
Exocrine Glands
secrete products into ducts or lumens or to the outer surface of the body
Endocrine Glands
secrete products into interstitial fluid(which diffuses into blood) or blood
hormones are
chemical messangers released in one part of the body and regulate activity in other parts of the body
Local hormones
act on neighboring cells (paracrine) or the same cell that secreated them (autocrine)
Dose not enter the blood stream first
circulating hormones
enter the interstital fluid and then bloodstream
can be lipid soluble(bound to transport proteins)
or water soluble(freely disolved in body fluids)
Lipid soluble hormones
are bound to transport proteins for transport in body fluids
can be steroid or thyroid
water soluble hormones
are freely dissolved in body fluids
steroid hormones are
a form of lipid soluble hormone derived from cholesterol
examples: cortisol, testosterone, estrogens, progesterone, aldosterone
thyroid hormones are
a type of lipid-soluble hormones that is very ipid soluble and is a tyrosine ring with attached iodines
peptide and protein hormones are
a type of water soluble hormone made of chains of amino acids
hypothalamic releasing and inhibiting hormones
examples: insulin, glucagon,EPO, ADH, oxytocin, hGH, TSH, ACTCH
Biogenic amines are
A type of water soluble hormones with modified amino acids
examples: NE, epinephrine, dopamine, serotonin, melatonin, histamine
main function of hormones
to maintain homeostasis and regulate many aspects of organ system functions
hormones leave secretory cell by
exocytosis or diffusion
what type of capillaries are found in endocrine glands
fenstrated capillaries wich are especially permeable type allowing for easy uptake of mater rom gland tissue
ACTH
Adrenocorticotropic hormone (corticotropin)
Source: anterior pituitary
ADH
Antidiuretic hormone (arginine vasppressin)
Source: posterior Pituitary
CRH
Corticotropin-releasing hormone
Source hypothalamus
DHEA
Dehydroepiandrosterone
Source: Adrenal cortex
EPO
Erythropoientin
Source: kidneys, liver
FSH
Follicle-stimulatin hormone
Source: Anterior pituitary
GH
growth hormone (somatotropin)
Source: anterior pituitary
GHRH
Growth Hormone-releasing hormone
Source: hypothalamus
GnRH
Gonadotropin-releasing hormone
Source Hypothalamus
IGFs
insulin-like growth factors (somatomedins)
Source: liver, other tissues
LH
Luteinizing hormone
Source: Anterior pituitary
NE
norepinephrine
Source: Adrenal medulla
OT
oxytocin
Source: psoterior pituitary
PIH
prolactin
Source: Anterior pituitary
PTH
Parathyroid hormone (parathormone)
Source: Parathyroids
T3
Triiodothronine
Source:Thyroid
T4
Thyroxine (tetraiodthyronine)
Source: thyroid
TH
thyroid hormone ( T3 and T4 collectivly
Source: thyroid
TRH
Thyrotropin-releasing hormone
source: hypothalamus
releasing hormones
stimulate the pituitary to release hormones
inhibiting hormones
supreses the pituitarys secreation og hormones
Gap junctions
enable the pass of nutrients, electrolytes and signaling molecules directly from the cytoplasm of one cell to another
paracrines
secreated by one cell and difuse to another in the same tissue and stimulate their physiology
Thyrotropin-releasing hormone (TRH)
promotes secreation of thyroid stimulating hormone(TSH) and prolactin(PRL)
corticotropin-releasing hormone(CRH)
promotes secreation of adrenocorticotropic hormone (ACTH)
Gonadotropin-releasing hormone (GNRH)
promotes secreation of follicle-stimulating hormone(FSH) and lutenizing hormone(LH)
Growth hormone-releasing hormone(GHRH)
promotes secreation of growth hormone(GH)
prolactin- inhibiting hormone(PIH)
inhibits secreation of prolactin (PRL)
somatostatin
inhibits secreation of growth hormone (GH) and thyroid-stimulatin hormone (TSH)
involution
shrinkage of tissue or organ by autolysis such as involution of the thymus after childhood and of the uterus after pregnancy
the Zona glomerulosa is the source of
mineralocorticoids
the zona fasiculata secretes
glucocorticoids and androgens
the zona reticularis secretes
glucocorticoids and androgens
the renin-angiotensin aldosterone syestem (RAA)
the mechanism in which falling blood pressure leads to an uncrease in aldosterone secretion
alpha cells secrete
glucagon which causes glycogenolysisa9the break down of glycogen into glucose) and gluconeogenesis (the synthases of glucose from fats)
RASIES BLOOD GLUCOSE LEVELS
Beta cells secrete
insulin and amylin
promotes synthasis of glycogen
how does insulin affect blood glucose levels
I lowers blood glucose levels
oligopeptides have how many amino acids
3-10
polypeptides have how many amino acids
more then 10
epinephrine and norepinephrine are secreted by what nervous system
the sympathetic nervous system
where are peptide hormones stored and what are a few examples
Examples:dopamine, epinephrine, oxytocin
stored in secretory vesicles of endocrine cell
are steroids and thyroid hormone hydrophobic or hydrophillic
hydrophobic
bound hormone is
a hormone attached to a transport protein
saturation is the condition iin which
all the receptor molecules are occupied by hormone molecules
signal amplification or the cascade effect is when
one hormone molecule triggers the sythesis of not many enzyme molecules
down regulation is the process in which
a cell reduces its receptor population and thus becomes less sensitive to a hormone
synergistic effect
an effect in which two hormones work together to cause a greater effect
permissive effectsis when
one hormones enhances the traget organs response to a second hormone
antagonistic effect
when one hormone oposes the action of another hormone
Metabolic clearance rate (MCR)
the rate of hormone removal
general adaptation syndrome (GAS) is
the way that the body reacts to stress
the alarm reaction causes an increase in
angiotensis and aldosterone
stages of stress response
alarm reaction
stage of resistance
stage of exhaustion
the thymus is the site of
maturation of T cells and secretes several hormones
the throid is composed of mostly
thyroid follicles
mineralocorticoids regulate
the bodys electrolyte balance
glucocorrticoids regulate
metabolism of glucose
renal reflexes involves the
kidney
growth hormone stimulates the release of what into blood
fatty acids and glycerol
growth hormone stimulates the synthesis of what by the liver
glucose
what is the most abundant hormone secreted by the thyroid
thyroxine T4
which class of hormones binds to an intracellular receptor and directs new mRNA and protein synthesis
steroid hormones
parathyroid hormone plays an important role in
rasing blood calcium levels
following hypoglycemia which hormones will be elevated
glucagon
Neural stimuli
nerve fibers soome endocrine glands and elicit the release of their hormones
Hormonal stimuli
hormones from the hypothalamus regulate secretionn by the anterior pituitary gland and pituitary hormones stimulate other endocrine glands to release thyroid hormone, sex hormone, and cortisol
Humoral Stimuli
blood borne stimmuli
how is cAMP produced
glucagon binds to the surface of a liver cell, its receptor activates a G protein, which activates the membrane enzyme that produces cAMP (andenylate cyclase)
Somatostatin inhibits
cAMP synthesis