Endocarditis & Iron deficiency Anemia Flashcards
an inflammation of the endocardium (inner lining of the heart) from a pathogen that has damaged endocardial tissue
endocarditis
What are the types of inflammatory diseases of the heart?
Infective Endocarditis (endocardium) Rheumatic Endocarditis ◦A unique form of Infective Endocarditis Myocarditis (myocardium) Pericarditis (pericardium)
How can infective endocarditis be classified?
as an acute or subacute infection
How is acute infective endocarditis caused? Which organism is involved?
- Caused by a new infection
* Organism - frequently staphylococci
How is subacute infective endocarditis caused? Which organism is involved?
- Occurs in an already defective heart valve
* Organism – often streptococci or E.coli
What is infective endocarditis?
Microbial infection of the endocardium
Deformity or injury of endocardium
What can occur as a result of infective endocarditis?
Results in clot formation on endocardium
Infective organisms invade clot &; form lesion
What do the lesions (vegatations) form and become as a result of the infective organisms invading and forming a clot?
thromboemboli
What are some examples of infective organisms?: (usually bacteria)
◦ Staphylococci, Enterococci or Pneumococci, Streptococci ◦ E.coli ◦ Rickettsia ◦ Fungi – Candida, Aspergillus ◦ Chlamydiae
What can cause the progression of infective endocarditis?
◦ Tears in endocardium ◦ Deformities of valve leaflets ◦ Dehiscence of prosthetic valves ◦ Deformity of the chordae tendineae ◦ Abscesses
What do the signs & symptoms of endocarditis develop due to?
Toxic effect of the infection
Destruction of the heart valves
Embolization of fragments of vegetative growths
What are the signs & symptoms of endocarditis?
*fever and new heart murmur Petechiae- skin small pinpoint hemorrhages Splinter hemorrhages of nails ◦ Black lines or red streaks on nails Roth Spots Janeway Lesions Osler’s Nodes
What are roth spots?
◦ White spots seen on retina
◦ Round or oval
What are janeway lesions?
◦ Painless, hemorrhagic lesions
◦ Palms, soles, nose, ear
what are osler’s nodes?
◦ Small painful nodules
◦ Tender, red lesions, white centers
◦ On fingers & toes
What are the risk factors for endocarditis?
Frequent introduction of pathogens Valvular heart disease-Valve replacement or repair IV drug abuse Indwelling IV catheters-esp if IV tip lies near heart Recent dental work Compromised immune system Previous endocarditis Recent body piercing or tatooing
What are the labs and diagnostics done for endocarditis?
Inflammatory process:
Echocardiogram
Kidney damage
◦ Anemia - low hemoglobin
Infection:
◦ Positive blood culture-definitive diagnosis
◦ ASO Titer (Antistreptplysion O titer)
Blood test to measure antibodies produced by
the groups A-Streptococcus bacteria
A-strep can cause Bacterial Endocarditis