Endo V Flashcards
DM I
autoimmune destruction of B cells
HLA-DR3/4 association
DKA common
see islet leukocyte infilrtation
DM II
insulin resistance
obesity association
genetic predisposition
amyloid deposits in islets
kussmaul respirations
rapid fast breathing - with DKA
DKA
anion gap metabolic acidosis
-can get rhizopus - mocurmycosis infection
in DM I
-not in DM II - insulin present - prevent lipolysis
tx of DKA
IV fluid
IV insulin
potassium
glucagonoma
tumor pancreas a cells
dermatitis, diabetes, depression
necrolytic migratory erythema
insulinoma
tumor of pancreas B cells
high insulin - hypoglycemia
whipple triad
- low blood glucose,
- sx of hypolglycemia
- resolution of sx with normalization of glucose
tx - resection
carcinoid syndrome
neuroendocrine cell tumor
rule of 1/3
-1/3 will met, present with 2nd malignancy, multiple
secrete high 5-HT - serotonin
GI carcinoid
no sx - serotonin - first metabolism in liver
5-HIAA in urine
with carcinoid syndrome
zollinger ellison syndrome
gastrinoma - of pancreas or duodenum
acid hypersecretion - recurrent ulcer duodenum and jejunum
abdominal pain and diarrhea
secretin stimulationt est
gastrin elevated after secretin - ZES
secretin should suppress gastrin levels
ZES association
MEN 1
MEN syndromes
multiple endocrine neoplasia
-auto dom
MEN 1
parathyroid tumor
pancreas - ZES, insulinoma, VIPoma
pituitary - PRL or GH
