endo cram Flashcards
Treat Hyperprolactinaemia
d2 agonist bromocriptine
acromegaly
d2 agonist somatastatin analogue to shrink tumour like octeotride
insipidus
desmopressin v2 agonist for cranial
Bendroflumethiazide for nephrogenic, thiazide
siadh
demeclocycline, v2 binder
Hypothyroidism
levothyroxine sodium, liothyronine sodium for myxoedema coma
Hyperthyroidism
Thionamides Daily. Reduce conversion of t4 to t3 in tissues and block graves autoantibodies.
Potassium Iodide for pre-surgery and emergencies. inhibits iodination and peroxide formation
Radio Iodine taken up by follicles and destory cells
beta blockers for immediate symptom relief.
cushings
metyrapone, 11 beta hydroxylase, pre surgery
ketoconazole cyp450 inhibitor
conns
spironolactone mineralocorticoid r antagonist, k+ sparing diuertic.
Addisons
hydrocortisone
prednisolone
dexamethasone
fludrocortisone mineralocorticoid
the other three are glucocortiocoids with decreasing affinity for mineralocorticoid receptors.
PCOS
Clomiphene, oestrogen antagonist
Metformin, increase insulin sensitivity.
Contraception
oestrogen and progesterone to upregulate cervical mucous and counteract androgenic effects from low lh/fsh
menopause
give hrt - oestrogen. and progesterone
SERMS
selective oestrogen receptor agonist/antagonist.
oestrogenic good for bone anti good for breast and uterus
VIT D deficiency
ergocalciferol and cholecalciferol are vit d replacements.
give alfacalcidiol for renally impaired patients.
Osteoporosis
Oestrogen hrt
bisphosphonates osteoclast inhibitor
Denosumab rank l inhibitor
Teriparatide recombinant pth
