End-stage renal disease Flashcards
Kidney physiology function (3)
- Filters 1700L of blood/day
- Process 1.5L urine/day
- Maintain homeostasis
Nephron
Funtional unit of kidney
Glomerulus
Primary site of the filtration process
Kidney function 6
- Regulates body fluids
- Eliminates metabolic waste
- Regulate osmolality of the ECF via action of ADH
- Regulate BP through the renin-angiotensin-aldosterone
- Activates vit D, Regulates calcium and phosphate
- Production of RBC’s
Glomerular Filtration Rate norms (GFR) ml/min
Males: 97-137
Females: 88-128
GFR deteriorates in CKD (5 stages)
- more than 90 ml/min GFR with kidney damage
- 60-89 ml/min
- 30-59 ml/min
- 15-29 ml/min - pre dialysis
- less than 15 ml/min
End stage renal disease requires…
Dialysis
Kidney function is inadequate to sustain life.
Primary causes (8)
- Diabetes
- Hypertension
- Glomerulonephritis
- Polycystic Kidney disease
- IgA nephropathy
- Lupus
- Analgesic abuse
- AIDS and cancer
Kidney malfunction
Metabolic acidosis hypertension Left ventricular hypertrophy Anaemia Peripheral neuropathy Muscle weakness Autonomic dysfunction Elevated tri glycerides
Clinical manifestations
Jaundice-yellowing Portal hypertension hepatic encephalopathy Oedema Fatigue muscle atrophy anaemia
Hemodialysis lowers
physiological health
functional health
psychological health
Physiological effect of KD
Muscle wasting
Effects of exercise training (7)
- increase exercise capacity
- increase VO2 peak (21-42%)
- increase Hct and Hb levels
- Improved lipid profiles
- Improved glucose metabolism
- Improved BP control
- Improved muscles strength
Functional assessments
Sit to stand 6m timed walk 10m timed walk grip strength ADL BP
Avoid
1RM
HR as an indicator
use RPE instead
Ex Prescription strength
- low weight
- build up reps during 1st hour dialysis
- 4-6x per week
Ex prescription flexibility
- After dialysis
- leg and back stretching
- 3x15s holds
Ex prescription aerobic
- 30min
- 4-6x per week
- non weight bearing due to joint pain
- Use RPE scale 12-15
Strongest predictors of mortality in ESRD
skeletal muscle wasting