End Stage Liver Disease Flashcards
Liver Cirrhosis
end stage of liver disease. constant inflammation and damage to the liver results in fibrotic scar tissue
causes
alcoholic liver disease NAFLD Hep B Hep C budd chiari syndrome alpha-1-trypsin deficiency autoimmune drugs
signs
liver disease symptoms: jaundice ascites spider naevia palmar erythema hepatomegaly tremor dupuytren's contracture
investigations
LFTs - albumin reduced, prothrombin increased
U+Es - hyponatraemia
alpha-fetoprotein - cancer
USS fibroscan - check elasticity of liver MRI/CT endoscopy - varices transient elastography
management
better diet exercise avoid alcohol manage underlying condition liver transplant
acute attack of the liver
WHAAC: Worsening jaundice Hepatorenal syndrome Asterix and encephalopathy Ascites Co-agulopathy
no increased prothrombin time or bilirubin, presence of encephalopathy differentiates between acute attack and present chronic disease
what are the signs of alpha-1-trypsin deficiency
COPD and liver issues
what score is used to assess liver damage
Child Pugh score
what is an important test to do in acute setting
capillary blood glucose as the patient could be hypoglycaemic
what investigations should be done on a regular basis if a diagnosis of cirrhosis is given
upper endoscopy - check for varices
liver USS - hepatocarcinoma
