EN7

Question 1

name the 3 causes of adrenocortical failure

Answer 1

TB addison’s disease
autoimmune addison’s disease
congenital adrenal hyperplasia

Question 2

what are the consequences of adrenocortical failure

Answer 2

hypotension
hyponatremia
hyperkalaemia
low blood glucose
high ACTH
pigmentation
vitiligo
death

Question 3

what is POMC made up of

Answer 3

ACTH, MSH, endorphins, enkephalins, other peptides

Question 4

what are the tests for addison’s

Answer 4

9am cortisol
ACTH level
SynACTH
blood test

Question 5

what are results for addison’s patient

Answer 5

low 9am cortisol level

low cortisol level after synACTH test

Question 6

what causes congenital adrenal hyperplasia

Answer 6

enzyme defiency which causes lack of hormone production and enlarged adrenal gland due to constant stimulation of ACTH

Question 7

what are the 3 types of enzyme deficiency from congenital adrenal hyperplasia and what are the consequences

Answer 7

21: virilisation, hirsutism, early puberty, addison’s disease (hypotension, low Na, high K, prone to infection, low glucose etc.)
11: hypertension, hypokalaemia, hypernatremia, virilisation
17: no puberty, prone to infection, low glucose, low K, high Na, hypertension