Embryology of respiratory system Flashcards

1
Q

period of lung development

A

week 3-after birth

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2
Q

out pocketing at the cranial end of the gut tube

A

respiratory diverticulum

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3
Q

origin of lung buds

A

respiratory diverticulum

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4
Q

middle ridge between the gut tube and the respiratory diverticulum

A

tracheoesophageal rudge

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5
Q

germ layer that forms gut tube

A

endoderm

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6
Q

esophagus ending in pouch- not hole

A

esophageal atresia

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7
Q

attachment forming between esophagus and trachea

A

tracheoesophageal fistula

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8
Q

failure of endoderm to proliferate rapidly enough to keep up with rest of embryo results in

A

esophageal atresia

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9
Q

failure of separation of trachea and esophagus

A

tracheoesophageal fistuka

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10
Q

consequences of proximal atresia and distal fistula

A

air in stomach, milk + fluids in lungs
polyhydramnios

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11
Q

polyhydramnios

A

excessive amniotic fluid

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12
Q

secondary branches AKA

A

lobar branches

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13
Q

how many lobar branches on left and right

A

2 left
3 right

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14
Q

how many tertiary branches on each sides

A

10

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15
Q

bronchopulmonary segments

A

developed tertiary branches and are supplied by a branch of pulmonary anatomy

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16
Q

medial side of embryonic coelom is

A

visceral pleura

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17
Q

lateral side of embryonic coelom

A

parietal layer

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18
Q

visceral layer derivative

A

splanchnic

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19
Q

parietal layer derivative

A

somatic layer

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20
Q

when is pseudoglandular period

A

week 7-16

21
Q

what do the lungs resemble during the pseudo glandular period

A

exocrine glands
- no respiration is possible here

22
Q

when is the canalicular period

A

16-24 weeks

23
Q

survival of babies born before week 20

A

rarely survive

24
Q

terminal sac/saccular period

A

week 24-36

25
Q

terminal sac cells differentiate into which cells

A

type I and type II pneumocytes

26
Q

Type 1 pneumocyte function

A

gas exchange barrier

27
Q

type 2 pneumocyte function

A

surfactant secretion

28
Q

alveolar period

A

week 32- childhood

29
Q

when is the grey zone

A

week 23/24

30
Q

what is the grey zone

A

period before the surfactant forms

31
Q

liquid in fetal lung

A

Fetal lung liquid that is made by pulmonary epithelium
- stimulates fetal lung growth

32
Q

transpulmonary pressure gradient is present when

A

during apnea

33
Q

respiratory distress syndrome aka

A

hyaline membrane disease
- hyaline membrane forms around the alveoli

34
Q

what causes RDS

A

deficiency of surfactant

35
Q

RDS is seen when

A

in premature infants commonly with diabetic mothers

36
Q

pulmonary agenesis

A

complete absence of a lung due to the respiratory diverticulum failing to split
- compatible with life

37
Q

pulmonary aplasia

A

absence of lung tissue but presence of rudimentary bronchus

38
Q

pulmonary hypoplasia

A

reduced terminal air sacs

39
Q

causes of pulmonary hypoplasia

A

congenital diaphragmatic hernia
oligohydromnios

40
Q

acinus refers to what

A

all of the branches distal to the terminal bronchiolus

41
Q

muscularization of pulmonary arteries is complete when

A

teen years

42
Q

until pulmonary artery muscularization occurs, what is the most important determinant of pulmonary blood flow

A

alveolar oxygen tension

43
Q

ductus venosus

A

shunt
artery passing liver and then mixes with venous blood and enters right atrium

44
Q

ductus arteriousus

A

blood bypasses lungs and enters circulation via the descending aorta

45
Q

formen ovale

A

how between right and left Atria
- right to left shunting

46
Q

foramen ovale and ductus arteriosus close when

A

after the first breath

47
Q

pulmonary hypertensions of the newborn

A

persistent fetal circulation
- occurs when the 2 holes do not close

48
Q

most of diaphragm comes from what

A

septum transversum

49
Q

congenital diaphragmatic hernia

A

abdominal organs ending up above the diaphragm
- can push liquid out of lung and cause pulmonary hypoplasia