embryology: hematopoeisis Flashcards

1
Q

What does hematopoiesis mean

A

Formation & development of blood cells

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2
Q

Why is hematopoiesis important

A

Blood cells are constantly lost/destroyed & to maintain homeostasis it must have self renewal capacity

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3
Q

What is the 2 steps in hematopoiesis

A
  1. Proliferation of progeny stem cells
  2. Differentiation & maturation of stem cell into functional cellular elements
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4
Q

In what two ways does fetal RBC differ from adult RBD

A
  1. Nucleus present
  2. HbF due to higher oxygen affinity
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5
Q

What is the 3 hematopoeitic waves

A
  1. Primitive hematopoiesis
  2. Pro-definitive hematopoiesis
  3. Definitive hematopoiesis
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6
Q

Where does primitive hematopoiesis occur

A

Along the wall of the yolk sac

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7
Q

What cells are formed in primitive hematopoiesis

A

Primitive erythrocytes, megakaryocytes & macrophages that remains in yolk sac or invade embryo to generate microglia

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8
Q

Where does pro-definitive hematopoiesis occur

A

Yolk sac

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9
Q

What cells are formed in pro-definitive hematopoiesis

A

Hematopoeitic progenitor cells that seeds embryo & liver

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10
Q

Where does definitive hematopoiesis occur

A

Intraembryonic in the dorsal aorta forming the endothelial to hematopoietic transition

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11
Q

What cells are formed in definitive hematopoiesis

A

Hematopoietic stem cells that seeds the liver & bone marrow

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12
Q

What organ replaces the yolk sac for blood cell production & when

A

Liver at 6-8 weeks

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13
Q

When does the RBC production shift to the bone marrow

A

Production of RBC reduce by the liver at 6 months pregnant & shifts to bone marrow

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14
Q

What is responsible for the liver to bone marrow RBC production shift

A

Cortisol

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15
Q

What is the function of the thymus & hormone present

A

Maturation of T lymphocytes into immunocompetent T cells
Thymosin hormone

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