ELM 6 Nernst equation Flashcards
What is the Nernst equation used for?
The Nernst equation calculates the equilibrium potential for a given ion based on its charge, the temperature, and the ratio of its concentrations inside and outside the cell.
: How does the Nernst equation relate to the resting membrane potential (RMP)?
The Nernst equation helps determine the equilibrium potential for individual ions, contributing to the overall resting membrane potential of a cell.
What does the Goldman-Hodgkin-Katz equation account for?
The Goldman-Hodgkin-Katz equation takes into account the permeabilities of multiple ions across the cell membrane to calculate the resting membrane potential.
Why is potassium (K+) considered the most influential ion in determining resting membrane potential?
Potassium ions are highly permeable through leak channels in the cell membrane, and their movement establishes the resting membrane potential, largely determining the cell’s negative charge at rest.
What is the significance of the resting membrane potential?
The resting membrane potential is essential for cellular function as it influences the excitability of neurons and muscle cells, as well as the movement of ions and the transmission of electrical signals across the cell membrane.
How does the Goldman-Hodgkin-Katz equation simplify when only one ion is permeable through the membrane?
When only one ion is permeable through the membrane, the Goldman-Hodgkin-Katz equation simplifies to the Nernst equation for that specific ion, allowing for the calculation of its equilibrium potential.
What did GHK equation prove?
Cl permeability doesn’t matter.
