EGFR inhibitors Flashcards
1
Q
EGFR inhibitors
A
afatinib
erlotinib
gefitinib
osimertinib
2
Q
3rd gen afatinib indication
A
metastatic nsclc with egfr positive exon 19 deletion
3
Q
afatinib acts by
A
EGFR HER2 HER4
ACTIVE AGAINST SECONDARY MUTATION OF T790M
4
Q
Afatinib side effect
A
Afatinib: diarrhea (more than erlotinib/gefitinib), rash, acne, stomatitis, paronychia, dry skin, pruritus, epistaxis, cheilitis; also monitor for pneumonitis, hepatotoxicity, GI perforation, and ocular toxicities
5
Q
doses of different egfr
A
Gefitinib: 250 mg orally, daily
• Erlotinib: 150 mg orally, daily (non–small cell lung cancer [NSCLC]); 100 mg orally, daily (pancreatic; empty stomach)
• Afatinib: 40 mg orally, daily (empty stomach)
