chemo therapy side effect

Question 1

cardiac toxicity

Answer 1

high total doses of the anthracyclines (doxorubicin, daunorubicin, epirubicin). In addition, high-dose cyclophosphamide as used in transplantation regimens may contribute to congestive cardiomyopathy
trastazumab

Question 2

pulmonary toxicity

Answer 2

high doses of bleomycin (>400 U). However, a number of other agents have been associated with pulmonary fibrosis (e.g., alkylating agents, methotrexate, nitrosoureas).

Question 3

nephrotoxicity

Answer 3

a potential toxicity of several agents (e.g., cisplatin, methotrexate, nitrosoureas). These agents can be associated with both acute and chronic toxicities. Other nephrotoxic agents such as amphotericin or aminoglycosides may exacerbate the problem.

Question 4

neurotixic

Answer 4

has been particularly associated with the vinca alkaloids, cisplatin, oxaliplatin, epipodophyllotoxins, taxanes, bortezomib, and ixabepilone. Peripheral neuropathy can cause considerable sensory and motor disability.

Question 5

hematologic impairment

Answer 5

can be persistent cytopenias, as with alkylating agents. Immunologic impairment is a long-term problem for patients with Hodgkin lymphoma, which may be due to the underlying disease as well as to the treatments that are used. Fludarabine, cladribine, and pentostatin, with or without rituximab, cause profound suppression of cluster of differentiation 4 (CD4) and CD8 lymphocytes
temozolomide

Question 6

selective toxicity: anthracycline

Answer 6

cardiomyopathy

Question 7

asparagine

Answer 7

anaphylaxis, pancreatitis

Question 8

bleomycin

Answer 8

pulmonary toxicity

Question 9

cisplatin

Answer 9

renal toxicity, neurotoxicity

Question 10

egfr

Answer 10

acneiform rash

Question 11

Fludarabine, cladribine, pentostatin, and temozolomide

Answer 11

: prolonged suppression of cellular immunity with heightened risk of opportunistic infection

Question 12

Ifosfamide and cyclophosphamide:

Answer 12

hemorrhagic cystitis ■ Ifosfamide: central nervous system toxicity

Question 13

Mitomycin

Answer 13

: hemolytic-uremic syndrome and other endothelial cell injury phenomena

Question 14

Paclitaxel

Answer 14

■ : neurotoxicity, acute hypersensitivity reactions (primarily from the vehicle)

Question 15

Vascular endothelial growth factor inhibitors:

Answer 15

gastrointestinal perforation, impaired wound healing

■

Question 16

Vinca alkaloids

Answer 16

: neurotoxicity

Question 17

trastazumab

Answer 17

reversible cardiomyopathy