common dosing regimen

Question 1

anal cancer ccrt

Answer 1

captabine 825mg/m2 bd on rt day
mitomycin 10 mg/m2 d1&d29
rt 5500cgy 6 wks
Or
5fu+ mitomycin
5fu+cpl
5fu: 1000mg/m2 iv cont D1-4

Question 2

brain ccrt

Answer 2

rt 200/day total 6 wks
temozolomide 75mg/m2 6 wks with radiation therapy after 4 weeks 150mg/m2 d1-5
repeat temozolomide every 28 days upto 6 cycle

Question 3

breast cancer adjuvant

Answer 3

a60
c 600 d1
pacli 175mg/m2 3wkly
in dose dense 2 wkly

Question 4

tamona
anastrozole
letrozole

Answer 4

tamona 20 mg pod
anastrozole 1 mg pod
letrozole 2.5 mg pod

Question 5

cervical cancer regimen

Answer 5

pacli 135 mg/m2 d1
cpl 75mg/m2 d2
if carbo give auc 5

Question 6

xelox

Answer 6

cap 825mg /m2 d1-14 d22-35
oxaliplatin 50mg/m2 d1. 8.22..29
rt 5040cgy 1.8 gy/day

Question 7

mayo clinic

Answer 7

5fu 425mg/m2 d1-5
leuco 20mg/m2 d1-5 admin before 5fu
6 cycle

Question 8

folfox4

Answer 8

oxaliplatin 85mg/m2 d1
rules2,4,6
2 means 200 mg/m2 leucovorin on one hand d1d2
and on other hand 400mg/m2 bolus than 600mg/m2 cont infusion over 22 hours d1 &d2

Question 9

xelox

Answer 9

ox 130mg/m2 d1

capecitabine 1000mg/m2 d1-14

Question 10

dose of captabine

Answer 10

with rt 825
with combi 1000
single 1250

Question 11

pacli carbo on head neck, endometrium, lung

Answer 11

pacli 175mg/m2 over 3 hours d1
carboplatin auc 5 d1
but if cisplatin than 75mg/m2 iv on day 2
with gcsf 5 microgram/kg/day days 4-10

Question 12

small cell lung cancer

Answer 12

etoposide 80mg/m2 d 1-3

cisplatin 80mg/m2 d1

Question 13

EMACO

Answer 13

Etoposide 100mg/m2 D1,2
Methotrexate 100mg/m2 bolus than 200mg/m2 12 hours D1
Actnomycin 0.5 mg/m2 on D1,2

CO schedule D8
Cyclophophamide 600mg/m2 D8
Oncovin/ vincristine 1mg/m2 D8
Give chemo 2 weekly
Most common side effect:
Myelosuppression
Stomatitis, bladder toxicity, neurotoxicity

Question 14

VAC IE

Answer 14

Vincristine 2 mg iv bolus D1
Doxo 75mg/m2 D1
Cyclo 1200 mg/m2 D1
,,,,,,
Ifosfamide 1800mg/m2 D1-5
Etoposide 100mg/m2 D1-5
Common toxicity
Myelosuppression
Bladder toxicity, hemorrhagic cystitis, cardiomyopathy, neurotoxicity

Question 15

ABVD

Answer 15

Doxo 25mg/m2 d1,15
Bleomycin 10 iu /m2 bolus
Vinblastine 6mg/m2 ns
Dacarbazine 375 mg/m2 d1,15
Main side effect is
Myelosuppression
Neutropenia, cardiomyopathy, pulmonary toxicity

Question 16

RCHOP

Answer 16

Inj Rituximab
- Inj Cyclophosphamide -
-Inj Doxorubicin
- Inj Vincristine
- Prednisolone
 375mg/m2, N/S
 750mg/m2, N/S
 50mg/m2, N/S
 1.4mg/m2 (max 2mg), N/S  100mg/d (Low grade)
 40mg/m2 (intermediate)

Question 17

Folfiri

Answer 17

Inj Irinotecan - Inj Folinic acid - Inj 5FU bolus -Inj 5FU

180mg/m2, 500ml N/S 90min D1
 200mg/m2 D1
 400mg/m2, Bolus D1 
2400mg/m2 continuous 46 hour infusion D1