Effector T

Question 1

How do T cells get to the site of infection?

Answer 1

Chemokine gradient

Adressin and integrin

Question 2

How do T cells induce apoptosis ?

Answer 2

Performing makes pore for granzyme
Fas ligand on T cell and fas receptor on target cell

Both pathways upregulate caspase

Question 3

Helper T cell functions

Answer 3

Macrophages activation
B cell activation
Regulation
Delayed type hypersensitivity response

Question 4

What is delayed type hypersensitivity?

Answer 4

Allergic response that takes some days to occur
Sensitisation = expose to allergen
Effector = in second exposure trigger a response
Helper T secrete cytokines

Question 5

5 types of helper T

Answer 5

Th1 pro inflammation
Th2 increase anti multicellular response
Follicular hT generate isotope switched antibodies
Th17 control bacteria
Treg regulate activation of other T

Question 6

Difference between memory T and B?

Answer 6

T don’t have isotope switching if affinity maturation

Response doesn’t improve over time

Question 7

Categorise memory T cells

Answer 7

Effector = CD45RA-CCR7- Local memory 
Central= CD45RA-CCR7+ Go back to spleen or lymph node = long lasting

Question 8

What happened when T cells get exhausted?

Answer 8

The CD8 pool gets smaller

PD1 (programmed death) receptor produced making it harder to activate T cells