EENT: Mouth/Throat- Bacterial pharyngitis and acute laryngitis Flashcards
Which mouth/throat disorder(s) can be bacterial?
A. Pharyngitis
B. Oral candidiasis
C. Herpetic gingivostomatitis
D. Acute Laryngitis
A. Pharyngitis
D. Acute Laryngitis
Which mouth/throat disorder(s) are viral?
A. Pharyngitis
B. Oral candidiasis
C. Herpetic gingivostomatitis
D. Acute Laryngitis
C. Herpetic gingivostomatitis
Which mouth/throat disorder(s) are fungal?
A. Pharyngitis
B. Oral candidiasis
C. Herpetic gingivostomatitis
D. Acute Laryngitis
B. Oral candidiasis
What condition typically presents with the following symptoms?
–Fever > 38˚
–Tender anterior cervical adenopathy
–Lack of a cough
–Pharyngotonsillar exudate
GABHS
Centor Criteria:
3 sxs= 90% likely, treat without testing
1 sx= unlikely
What condition would you treat with the following medications?
- Penicillins/Cephalosporins 1st gen
- Erythromycins/Macrolides (if penicillin allergy)
Treatment for GABHS
MOA: inhibits bacteria cell wall synthesis
Penicillins (Beta-lactams)
–Hypersensitivity(rash, hives, itching, swelling of lips, tongue, mouth, or throat)
–Mild diarrhea, vomiting, nausea, oral candidiasis
Adverse events/side effects of Penicillins (Beta-lactams), which are used to treat bacterial pharyngitis
–monitor for signs of anaphylaxis during first dose
–opportunistic infection (fever, chills, unhealed sores, white plaques in mouth or vagina, purulent vaginal discharge, fatigue).
Efficacy or monitoring for Penicillins (Beta-lactams), which are used to treat bacterial pharyngitis
Which medication has interactions with the following drugs?
- Probenecid may increase the serum concentration of _____?
- Tetracycline Derivatives: May diminish the therapeutic effect of ______–->bacteriostatic with bactericidal
- ****_______ may enhance the anticoagulant effect of Vitamin K Antagonist-warfarin******
Drug interactions for Penicillins (Beta-lactams), which are often used to treat Bacterial pharyngitis
Which medication has the following MOA:
Inhibitor of translation and transcription:
- Inhibits RNA-dependent protein synthesis at the chain elongation step;
- Binds to the 50S ribosomal subunit resulting in blockage of transpeptidation
MOA for Erythromycin (&Macrolides), which can be used for treatment of bacterial pharyngitis
****What is an alternative treatment for bacterial pharyngitis in a patient that has a penicillin allergy?
Erythromycin (macrolide)
Which medication has the following events/side effects
- Hypersensitivity
- *****Abdominal pain, anorexia, diarrhea (GI disturbances)*****
- ****QTc prolongation–torsade de pointes, ventricular arrhythmia, ventricular tachycardia
- Pruritus, rash (Rare: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis)
- Ototoxicity (hearing loss)
- Cholestatic jaundice (rare now with removal of estolate salt)-use caution in patients with impaired hepatic function
Events/side effects of Erythromycin (macrolide), which is a medication used to treat bacterial pharyngitis
Which medication has the following efficacy/monitoring recommendation?
–Report immediately any unusual malaise, nausea, vomiting, abdominal colic, or fever; skin rash or itching; easy bruising or bleeding
Erythromycin (macrolide)
Which medication has the following drug interaction:
***Effects on CYP450****:
- Substrate of CYP2B6 (minor), CYP3A4 (major)
- Inhibits CYP3A4 (moderate)
Interactions for Erythromycin (macrolide), a medication used to treat bacterial pharyngitis
What medication has the following unlabeled use?
*****Gastrointestinal prokinetic*****
Erythromycin (macrolide)
