EENT- Ear Flashcards

1
Q

What condition has the following clinical presentation:

Painful erythema and edema of the ear canal skin; often with purulent exudate

A

Otitis Externa

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2
Q

–Which condition has the following causes?

  • Water exposure; i.e. swimmer’s ear
  • Mechanical trauma; eg. Scratching, cotton applicators
  • Infections with gram-negative rods:
    • Pseudomonas
    • Proteus
    • fungi-Aspergillus (common in pts with hearing aids)
A

Otitis Externa

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3
Q
  1. Decrease excessive moisture: (Acetic Acid (VoSol) Otic +/- hydrocortisone or 50/50 mixture of isopropyl alcohol/white vinegar)
  2. Treat bacterial/fungal infection with antibacterial topical solutions (Aminoglycosides or fluouroquinolones)
  3. Oral- fluoroquinolones ciprofloxacin, effective against Pseudomonas
A

Treatment for Otitis externa

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4
Q

•Antibacterial topical solutions (generally 7-10 days)

  • –Aminoglycoside
    • Neomycin/Polymyxin/HC
    • Gentamicin/tobramycin with/without corticosteroids (ophthalmic solutions)
  • **Fluoroquinolones-ciprofloxacin
A

**Treatment for Otitis Externa caused by bacteria or fungus**

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5
Q

Which Otitis Externa medication?

–Contains: Acetic Acid, Propylene Glycol Diacetate, and Hydrocortisone

–Dosage: Instill 3-5 drops in ear(s) every 4-6 hours

–ADEs: Transient burning or stinging after instillation in the acutely inflamed ear

A

VoSol HC Otic

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6
Q

The following describes which antibiotic?

–Mixed antibiotic product with corticosteroid

–Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits

A

•Neomycin sulfate, Polymyxin Sulfate and Hydrocortisone Otic Solution and Suspension

–>used to treat otitis externa

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7
Q

–ADEs: pain, fungal superinfection, pruritus

–Dosage: Instill 0.25 mL (contents of 1 single-dose container) into affected ear twice daily for 7 days

A

Fluoroquinolones- Ciprofloxacin Otic (for treatment of OE)

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8
Q

What is this a treatment for?

•Aminoglycosides Ophth Solution

  • Gentamicin or Tobramyin
    • +/- hydrocortisone
  • Vestibular ototoxicity tympanic perforation
A

Otitis Externa

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9
Q

Which condition?

•Otalgia, erythema and hypomobility of tympanic membrane

  • Usually precipitated by a viral URI that cause eustachian tube dysfunction
A

Acute Otitis Media

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10
Q

Which condition is commonly infected with the following organisms?

  • Steptococcus pneumoniae
  • non-typable H influenza
A

Acute Otitis Media

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11
Q

The following less common causative agents of which condition?

–Streptococcus pyogenes (Group A beta-hemolytic streptococcus)

–Staphylococcus aureus

–Moraxella catarrhalis

A

Acute Otitis Media

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12
Q
  1. Amoxicillin (1st line): Children >3 months and <40 kg: Oral: 80-90 mg/kg/day divided every 12 hours. Max: 3g/day
  2. Erythromycin plus sulfonamide (alt for PCN allergy)
  3. Cefaclor (alt for PCN allergy)
  4. Amoxicillin-clavulanate: (amoxicillin 600 mg and clavulanate potassium 42.9 mg per 5 mL)
A

Treatment options for AOM

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13
Q

AOM caused by Staph aureus can occur in which type of patients?

A

can occur in patients with chronic suppurative otitis media

  • may be associated with persistent otorrhea that follows insertion of tympanostomy tubes
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14
Q

Which medication and for what condition?

Children ≥3 months and <40 kg:

  • Oral: 90 mg/kg/day divided every 12 hours x10d in children with severe illness and when coverage for β-lactamase positive H. influenzae and M. catarrhalis is needed
A

Amoxicillin-Clavulanate

Possible tx for AOM

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15
Q

•When should you consider one of the following cephalosporins:

–Cefdinir 14 mg/kg per day orally in one or two doses (maximum 600 mg/day)

–Cefpodoxime 10 mg/kg orally in two doses (maximum 400 mg/day)

–Cefuroxime suspension 30 mg/kg per day orally divided in two doses (maximum 1 g/day)

–Cefuroxime tablets 250 mg orally every 12 hours

-Ceftriaxone 50 mg/kg IM once per day (maximum 1 g/day) for one to three doses

A

Treatment for AOM for a patient with penicllin allergy but did NOT experience an immediate type 1 hypersensitivity rxn (anaphylaxis, angioedema, bronchospasm, or urticaria)

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16
Q

ADEs for which drug group?

  • Rash, diarrhea, increased transaminases
  • Vaginitis
A

Cephalasporin group

17
Q

Cephalosporins group requires dose adjustment with ______ impairment

A

renal

18
Q

What is the first line tx for AOM due to increasing prevalence of S pneumoniae strains and other otopathogens that are not fully susceptible to amoxicillin?

A

**Amoxicillin-clavulanate**

dose: amoxicillin 875 mg with clavulanate 125 mg orally twice daily.

19
Q

When would you use the following high-dose options:

Amoxicillin 1000 mg with clavulanate 62.5 mg, extended-release, orally twice daily

Amoxicillin 2000 mg with clavulanate 125 mg, extended-release, orally twice daily

A

•Adults with OM that are at high risk for severe infections or infections with resistant S. pneumoniae

(eg, those who live in regions with ≥10 percent penicillin-non-susceptible S. pneumoniae, >65 y/o, are immunocompromised, recently hospitalized, or have used antibiotics in the past month),

20
Q

The following are treatment options for ____ without a PCN allergy

  • Cefdinir, 300 mg orally twice daily or 600 mg once daily.
  • Cefpodoxime, 200 mg orally twice daily.
  • Cefuroxime, 500 mg orally twice daily.
  • Ceftriaxone, 1 to 2 g IM or IV once daily for three days.
  • 1 dose might be sufficient in peds but clinical trials have demonstrated 3d course to be more effective
A

1st line tx for a patient with OM that has a penicillin allergy without severe reactions, and who do not have a known allergy to a cephalosporin

21
Q
A
22
Q

treatment options for patients with a known severe allergy to beta-lactam antibiotics or who have a known allergy to cephalosporins (Which condition???)

  • Doxycycline, 100mg PO Q12hrs
  • Azithromycin, 500 mg orally on day 1, then 250 mg orally days 2 through 5
  • Clarithromycin, 500 mg orally every 12 hours
A

OM in adults

23
Q

S. pneumoniae isolates haven a high rate of resistance to _______

A

macrolides (azithromycin and clarithromycin)

24
Q
A
25
Q

•Children <2 years, children with AOM and TM perf, and children w/ a hx of recurrent AOM be treated for ____days

A

10 days

26
Q

•Children ≥2 years without tympanic membrane perforation or a history of recurrent AOM be treated for _____ to ____days.

A

5 to 7 days

27
Q

Which medications should not be used for treatment of AOM in adults?

A
  • Bactrim and macrolides b/c of high resistance
  • Clinda (b/c no activity against H. influenza)