ECBD Modulation and Genetics Flashcards
What role does the endocannabinoid system (ECS) play in homeostasis?
The ECS is crucial in maintaining homeostasis by regulating metabolism, stress responses, and various physiological functions.
How does acute exercise affect endocannabinoid levels?
Acute exercise has been shown to consistently increase levels of endocannabinoids such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG).
What factors influence the impact of exercise on the endocannabinoid system?
Exercise intensity, physical fitness, timing of measurement, and whether the individual is in a fasted state affect how exercise influences ECS levels.
How do genetics influence the endocannabinoid system?
Genetic variations, like SNPs in the FAAH gene, can affect the levels and activity of endocannabinoids, impacting stress response and susceptibility to psychiatric disorders.
What are the therapeutic implications of modulating the ECS?
Modulating the ECS, through interventions like exercise, may offer therapeutic benefits for stress-related conditions such as PTSD, anxiety, and depression.
What role do enzymes like FAAH play in the ECS?
Enzymes like FAAH are responsible for degrading endocannabinoids, and inhibiting these enzymes can increase endocannabinoid levels, providing pain relief and reducing stress.
How does FAAH inhibition affect stress response?
FAAH inhibition can reduce the negative affective response to stress, potentially offering a mechanism for decreasing anxiety and enhancing mood.
What do researchers recommend regarding exercise for ECS health?
Regular exercise is recommended as a non-pharmacological way to enhance the endocannabinoid system, potentially mitigating stress and improving overall well-being.
What future research is suggested for the ECS?
Further studies are needed to explore personalized exercise regimens as preventive and therapeutic measures targeting the ECS for stress-related diseases.
How might endocannabinoids mediate the analgesic effects of exercise?
Endocannabinoids released during exercise may help refill energy stores and mediate the natural analgesic and mood-elevating effects associated with physical activity.
