CBD Flashcards
What receptors does CBD interact with and what are its primary effects?
CBD interacts with CB1, CB2, GPR55, TRPV, and PPARγ receptors, leading to neuroprotective, antiepileptic, anxiolytic, antipsychotic, anti-inflammatory, analgesic, and anticancer properties.
What concerns exist regarding the efficacy of CBD for mental health conditions?
While CBD is widely used for conditions like anxiety, depression, and bipolar disorder, there is insufficient scientific evidence to confirm its efficacy for these diseases.
What safety concerns has the FDA highlighted about CBD?
The FDA has noted potential harm from CBD, including liver injury, interaction with other drugs leading to serious side effects, and male reproductive toxicity in animal studies.
How does CBD’s mechanism of action differ at low and high doses?
At low doses, many of CBD’s effects are CB1 mediated, while at high doses, the mechanisms are less clear and involve multiple targets.
What are common misunderstandings about CBD in the public domain?
The public often misunderstands CBD’s benefits and harms, with many unsubstantiated health claims and confusion between its medical and non-medical uses.
What have clinical studies revealed about CBD’s effectiveness for nausea and vomiting?
Published trials have not substantiated cannabidiol’s utility for combating nausea and vomiting, including chemotherapy-induced conditions.
What evidence exists regarding CBD’s effect on anxiety?
A study involving social anxiety disorder subjects showed that a single dose of CBD (600 mg) significantly improved anxiety scores compared to placebo during a public speaking test.
What are the unknowns regarding long-term use of CBD?
Unknowns include the effects of sustained daily use, the level of intake that triggers known risks, and how different consumption methods affect intake and risk.
What challenges do regulators and clinicians face regarding CBD use?
Challenges include a lack of definitive clinical evidence for many of its purported benefits, potential for serious side effects, and the need for clearer guidelines for safe use.
How can CBD affect liver function?
CBD can cause liver injury, and its use alongside other medications that affect liver enzymes can increase the risk of hepatotoxicity.
