EC immunity Flashcards
Th2 cells function
Protection against extracellular pathogens, parasites and bacteria
Th17 cells function
Protection against extracellular pathogens, fungi and bacteria
Th1 cell function
Protection against intracellular pathogens
Function of Treg cells
Immunosuppression
What immunopathy do Th1 defects cause?
Autoimmunity and delayed type hypersensitivity (IV)
What immunopathy do Th2 defects cause?
Allergy and asthma
What immunopathy do Th17 defects cause?
autoimmunity
Th0 (native) cells differentiate to Th1 in response to what cytokines
IL12 and IFN-gamma
Th0 (native) cells differentiate to Th2 in response to what cytokine and what
IL-4 and GATA3 mediated transcription
Th0 (native) cells differentiate to Th17 in response to what cytokines and what
IL6 and or IL21 and STAT3/IRF4 mediated transcription
Th2 responses neutralising ……….
antibodies
Class switching of gut IgA1 to ……. in Th2 cells
Protease resistant IgA2
IL-5 increases ________-poiesis, b____ m____ release, activation and survival
IL-5 increases eosinopoiesis, bone marrow release, activation and survival
What do Eosinophils produce
ROS
major basic protein
RNases
Cationitic proteins
ROS
reactive oxygen species
What are cationic proteins against
Anti-helminth
Il-9 activates what cell type
Basophils
IgE binds to what cells leading to release of what
Basophil/mast cell –> release of histamine and cytokines
What is Th0 –> Th17 differentation driven by
IL-23, TGF-gamma, IL-6 and ROR-gamma mediated transcription.
Group A strep produces what virulence factors
Adhesins and invasins
Surface M protein
C5a protease
CD11b homologue
Streptolysin
speB
Protein G
Group A strep: Surface M protein inactivates what
C3b
What does CD11b (and so Strep A homologue) do?
Stick cells together
speB
Streptococcocal pyrogenic exotoxin B
What does speB degrades
IL-1beta
Function of protein G from group A strep
Binds IgG and human albumin
Tissue necrosis can be caused by what enzymes
Hyaluronidase
What is rheumatic fever due to
Molecular mimicry
What causes toxic shock
Non specific T cell activation
What type of antigen causes Toxic Shock
Superantigen
E coli OH174H7 obtained what toxin
Shiga-like toxin
What did UPEC obtain
adhesins
Where does helicobacter pylori reside and causes what
In stomach. Causes chronic inflammation, gastric ulcers and stomach cancer
Virulence factor of H.pylori
Outer membrane protein include putative adhesins, ferric transporters, flagella proteins. Catalse, urease
What extra thing do pathogenic H.pylori contain that commensals don’t
Extra pathogenicity island not found in commensal
What is the extra pathogenicity island of pathogenic H.pylori called, whats a gene it contains
CagPAI, superoxide dismutase
What does VacA of H.pylori disrupt
Late endosomal compartments
What does VacA target, leading to what release
Mitchondria leading to release cytC
Is cytochrome C toxic
Yes
What type secretion system does pathogenic H.pylori contain
IV
What receptor is used in fungal recognition, give an example and its substrate
Lectins
Dectin-1 for beta-glucan
Fungal recognition skews the response towards what T response
Th17
What cytokine receptor mutations can lead to susceptbility to fungal infections
IL-17 receptor
