Antiviral immunity I Flashcards
What type of immunity are cytokines part of
Innate
What are IFNs and their action
Interferons, antiviral proteins
What are CXC, CC, CX3C and C and their action
Direct cell migration, adhesion and activation
What is the function of interleukins?
Depends on IL member and cell type
What is TNF and its action
Tumour necrosis factor family, refulates inflammation and immune response
What is TGF-beta and function
Transforming growth factor beta, regulates immune cells
Do cytokines have a low or high Mr
Low
What cytokine do infected cells and DCs produce?
Type I IFNs
What do IFNs induce
ISGs
MHCI expression
APCs have higher pahgocytotic potential
NK cell activation
T cell activation
ISG meanign
Interferon stimulated gene
What type of cell are NK cells and their role
Granular lymphocytes, eliminate infected cells
What type of cell do NK cells kill
Ones that lack MHC class I
When MHC I is present where does the NK cell bind to?
Inhibitory receptor
Why can MHC I be absent in an infected cell
Virus wants to hide from T cell detection
What compoumds does NK cells release
perforin and granzymes
What is neutralisation
Ab can neutralise viruses by binding to proteins on surface of the virus –> prevents virus from binding to the receptors on host cells.
What is opsonisation
Fc receptors bind to Fc region of Ab-antigen complexes like viruses bound by Abs (IgG). Phagocytosis of immunoglobulin-bound virus can lead go the destruction of the virus.
What cell type allows for opsonisation
macrophage
