Autoimmune diseases Flashcards
What gene is a key factor in developing Tregs
Foxp3
Deficiency in Foxp3 leads to decreased dunction of what Treg cells. What is this disease called
CD4 CD25 Treg; IPEX
IPEX stands for
(immunodysregulation, polyendocrinopathy X-lined syndrome).
How do tregs work
Inhibitory cytokines –> membrane tethered TGFbeta
Cytolysis via granzymes
Cytokine depraviation
Target DC maturation
Pemphigus vulgaris is specific to which organ?
Epidermis
Symptoms of pemphigus vulgaris
Epidermal blisters
Oral mucosa erosion
Loss of epithelial cell adhesion
What is the autoantigen of pemphigus vulagirs
Desomose
What is the function of desmosomes
Cell-to-cell adhesion
Pemphigus foliaceus (PF) autoantigen:
Anti-Dsg1
Fogo selvagem
Endemic form of PF in rural brazil
PV therapy
Steroid /+ immunosuppresive drugs
How is SLIT performed and against what allergies (2)
Small amount of allergen under tounge, against dust mite allergy and atopic dermatitis
Rituxamab is an agonist to what
CD20, targets B cells for killing
What is lupus erythematosus (SLE)
Multisystem disorder usually affects young women
SLE: autoantibodies to
nuclear antigens
What is the ANA test
ANA test (antinuclear antibody
ENA indicates type of disease, what is it
extracable nuclear antigen
Symptom of SLE
Vasculitis
Chronic-discoid LE + trigger factor
Skin condition (lupus) that causes a rash that can potentially scar. UV light, exposure to cold, stress
Subacute cutaneous LE -SCLE symptoms
Lupus that causes red scaly rashes on the skin, polycyclic annular lesions/plaques.
Ro antigen is present in…. as….. makes complexes with …..
Ro antigen is present in nuclei as ribonuclear protein complexes with small RNAs
Therapies for LE
PRotection from UV
Chloroquin
Immunosuppression
