EBV and CMV Flashcards
acute lytic viral infection
virus expands in cell and leads to lysis of the cell
chronic lytic viral infection
productive viral infection in subset of cells..these cells can release the virus but will not lead to lysis
chronic lytic focal infection
carrier cells make virus…infect neighboring cells that start process over again
chronic lytic diffuse infection
infected cells and virus replicate together…cells are not lysed and will shed virus around
how is a latent and chronic viral infection different?
in chronic you are always making the infectious viral particles
in latent you do not make the infectious virus but just have the viral nucleic acids
how do herpes viruses maintain latency?
as an episome…or extrachromosomal DNA
EBV structure
dsDNA in isocahedral core
when does primary EBV infection become clinically apparent?
infection in older folk
what two cell types does EBV enter and replicate in?
endothelial and Cd21 B cells
how does EBV lead to some funky lymphocytes and what are thesE?
CD8 cells recognize the screwed up CD21 B cells and try to kill em…makes the CD8 cells look fluffy
two tests for EBV diagnosis
mono spot for heterophile antibodies…not great
EBV antibodies like for viral capsid antigen
How does EBV cause latent proliferation ?
the latently infected cells can produce more IL-10 which in this case leads to wild proliferation of B cells
what is the risk of this latent proliferation?
more divisions equals higher chance of mutation leading to cancerous state
ways to transmit CMV? (5)
saliva, transplacentally, genital secretions, transfusions/plants
what happens if pregnant mother has primary CMV infection?>
lots of organ defects in baby
