EBP in the case Flashcards
What is a systematic review?
Identify all relevant studies fitting predefined data
Systemically summaries validity and findings of the studies
Synthesis or integrate the findings
Principles of systematic review
Methodological rigour
Transparency
Reproducibility
Why are systematic reviews useful for researchers
Demonstrate paucity of evidence or show there’s no need for a new trial
Heir archy of evidence
Case reports Case control studies Cohort studies RCT's Systematic review
Narrative review
subjective
What analysis do systematic reviews often do
META ANALYSIS
Weighted average of results considered to be combnable
- fixed effect and random effects
Steps in a systematic review
Formulate
Components of a systematic review
Transparent about data collection
Metanalysis
Methological quality of included studies
2+ researchers doing key aspects of the study
Steps in a systematic review
Formulate the question Describe eligibility criteria Develop a protocol Search for studies Apply eligibility criteria Collect data from studies Access studes for risk of bias Summarize studies Synthesise findings Interpret results
PICO
population
innervation
comparator
outcome
Data collection - systematic review
Study design Participant characterisitcs Details of interventions Study methods Results
Potential sources of bias in RCT
Is it truly random? Omissions from analysis Honest reporting Blind assessment Blinding of participants and experimenters
COchrane risk of bias tool
All of studies included
- Scaled on blinding of outcome assessment, other bias, selective reporting etc
Reporting/publication bias
Significant findings are more likely to be published in actively disseminated and easily available places - easier to find
Need to ensure you don’t miss other studies - search the grey area- things not necessarily in research papers
Where can SR’s go wrong
Performed poorly
Contributing studies are biased
reporting/publication bias is present
