(E1) 3 - Odontogenesis Pt I: Early Tooth Formation Flashcards

Exam 1 - BLANKENSHIP

1
Q

Mandibular and maxillary arches arise primarily from the ____ with small contribution from ______

A

PA1
Frontonasal proess

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2
Q

Maxillary premolars and molars arise from ___________

A

maxillary process of PA 1

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3
Q

Where do all mandibular teeth arise from?

A

Mandibular process of PA1

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4
Q

Where do maxillary incisors arise from?

A

Frontonasal region (intermaxillary segment)

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5
Q

The early established oral cavity is lined by stratified squamous epithelium called the _______________

A

oral ectoderm

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6
Q

Epithelium covers the embryonic connective tissue called ____________

A

ectomesenchyme

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7
Q

What is ectomesenchyme made up of?

A

Derived from neural crest cells mixed with mesenchyme

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8
Q

~5-6 weeks of gestation, basal cells of the oral ectoderm proliferate faster creating a thickened band called the
_________________

A

Primary epithelial band

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9
Q

What does the primary epithelial band indicate?

A

Position of future dental arches

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10
Q

The primary epithelial band gives rise to two subdivisions. What are they?

A

Dental Lamina
Vestibular Lamina

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11
Q

What is the dental lamina?

A
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12
Q

What is the vestibular lamina?

A
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13
Q

In what direction does the formation of future dental arches occur?

A

Begins anterior and progresses posterior.

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14
Q

All teeth (and appendages) develop from two germ layers. What are they?

A

Oral Ectoderm
Ectomesenchyme

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15
Q

What is oral ectoderm?

A
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16
Q

What is ectomesenchyme?

A
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17
Q

What tooth structure does the epithelium (oral ectoderm) form?

A

Enamel

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18
Q

What tooth structures does the ectomesenchyme form?

A

Dentine, pulp, periodontal ligament, cementum, alveolar bone proper

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19
Q

___________ occurs between dental epithelium and ectomesenchyme → controls dental development

A

Reciprocal signaling

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20
Q

What steps of reciprocal signaling is ectoderm directed?

A

Inititaion

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21
Q

What steps of reciprocal signaling is ectomesenchyme directed?

A

Patterning and Morphogenesis

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22
Q

Reciprocal Signaling: Describe Initiation

A
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23
Q

Reciprocal Signaling: Describe Patterning

A
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24
Q

Reciprocal Signaling: Describe Morphogenesis

A
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25
Q

Chart Image - Germ Layer and Structures

A
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26
Q

What are the 3 parts of the tooth germ?

A

Enamel Organ
Dental Papillae
Dental Follicle

27
Q

What is the tooth germ responsible for?

A

Forms the mature tooth

28
Q

What germ layer is the enamel organ from?

29
Q

What germ layer are the dental papillae and dental follicles from?

A

Ectomesenchyme

30
Q

What does the enamel organ give rise to?

31
Q

What does the dental papilla give rise to?

A

Dentin and Pulp

32
Q

What does the dental follicle give rise to?

A

Cementum
PDL
Alveolar Bone

33
Q

______________ within primary epithelial band are thought to play a major role in tooth site initiation

A

Placodes (thickening epithelium)

34
Q

What are the signal types that affect placodes?

A

Stimulatory
Inhibitory
Regulatory

35
Q

Defects in signaling pathways lead to _____________ (3 things)

36
Q

What does tooth type mean?

37
Q

What does tooth shape mean?

A

Morphology

38
Q

Teeth mature _________ (direction)

A

anterior to posterior

39
Q

_____ teeth mature slightly ahead of ______ teeth

A

Mandibular
Maxillary

40
Q

What is a succedaneous tooth?

A

a permanent tooth that replaces a primary tooth

41
Q

Most permanent develop off the primary tooth dental lamina.

What is the first and last?
What is the exception?

42
Q

What are the stages of odontogenesis?

43
Q

_______ determines the site of the tooth

A

Dental epithelium

  • then transfers this potential to ectomesenchyme
44
Q

What are the characteristic events of the initiation stage?

45
Q

Where does the dental lamina and vestible form in the mouth?

A

Lamina = lingually
Vestibule = labially/bucally

46
Q

The dental lamina indicates initial __________

A

site of each tooth bud

47
Q

_______ determines tooth type

A

Ectomesenchyme!!!!

48
Q

How do teeth know where to form?

A

Based on spatially arranged regulatory signaling

49
Q

What do the oral ectoderm and dental ectoderm give rise to respectively?

50
Q

Stages of Development: Bud Stage

What is the functional stage and morphological appearance?

51
Q

What is happening in the transition from the bud to the cap stage?

52
Q

Stages of Development: Cap Stage

What is the functional stage and morphological appearance?

53
Q

_________ directs the folding and shape changes of the enamel organ.

A

Ectomesenchyme

  • shape of the tooth is set during this stage (morphogenesis)
54
Q

In what stage is the shape of the tooth set?

55
Q

Characteristic events of Early Cap Stage

56
Q

Where does the enamel knot appear first?

A

Early Cap Stage - (more visible in late cap)

57
Q

Dental epithelium aggregates to form _________

A

enamel knot

58
Q

Key roles of the enamel knot

59
Q

What is the functional stage and morphological appearance of the bell stage?

60
Q

In what stage does cytodifferentiation occur?

A

Bell Stage

61
Q

What are the four layers of epithelium formed from cytodifferentiation of the enamel organ?

62
Q

What are the characteristic events of the early bell stage?

A
  • the cervical loop is visible
  • dental papilla begins differentiating into pre-odontoblasts
  • secondary enamel knot appears (only in multi-cusped teeth)
63
Q

What are the characteristic events of Late Bell Stage?

A
  • cusp formation
64
Q

Image - Stages of Tooth Development