Dzs of the lens (Whitley) Flashcards

1
Q

Normal lense placement

responsibilities

A
  • behind iris, in front of vitreous
  • patella fossa
  • held in place by zonules
  • responsibilities
    • refraction
    • accomodation
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2
Q

Lens anatomy

A
  • Capsule
    • basement membrane surrounding lens
  • Anterior epithelium
  • Lens fibers
    • interdigitating layers
    • form Y sutures
      • upright anterior Y
      • inverted postierior Y
    • Cortex
    • Nucleus
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3
Q

Clinical anatomy of lens

A
  • second most imp refractive structure
    • cornea is number 1
  • transparent
  • no innervation
  • no vascular structures
  • lens epithelium
    • present at equator
    • lines anterior cortex
  • three major regions
    • cortex
    • nucleus
    • capsule
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4
Q

Lens formation

embryology

A
  • basement membrane becomes lens capsule
  • anterior lense capsule get thicker and thicker
  • posterior doesn’t
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5
Q

Lens fibers

A
  • Fibers continuously produced
    • compacted towards center of lens
  • lens becomes more dens/sclerotic with age
    • nuclear sclerosis
    • central nucleus gets hard
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6
Q

Dzs of lens

A
  • Cataract
    • opacity of lens or lens capsule
  • Subluxation
  • luxation
  • congenital abnormalities
    • microphakia
    • aphakia
    • lenticonus
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7
Q

Nuclear sclerosis vs cataract

A
  • Nuclear sclerosis
    • lens within a lens
    • bilateral
    • symmetric
    • center of lens
    • doesn’t interfere with fundus exam
    • can visualize tapetal reflex through sclerosis
    • no clinical interference with vision
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8
Q
A
  • Left: Cataract
  • Right: Nuclear sclerosis
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9
Q
A

Nuclear Sclerosis and Cataract

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10
Q

Classifying cataracts

Location

A
  • Structure of lens
    • capsular
    • subcapsular
    • cortical
    • nuclear
  • Direction
    • anterior
    • posterior
    • equatorial
    • polar
    • axial
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11
Q

Leukocoria

A
  • White pupil
    • usually means a cataract
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12
Q

Cataract classification

Schemes

A
  • stage of development
  • maturity
  • size
  • location of opacity within lens
  • age of development of cataract
  • consistency
    • fluid
    • soft
    • hard
    • sticky
  • etiology
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13
Q

Cataract

stages of maturity (amount of lens involved)

A
  • Incipient
    • ,15% total lens volume
  • Immature
    • early
    • late
    • 16-99%
  • Mature
    • 100% lense is cataractous
  • Hypermature
    • lens resorption
      • lens cortex liquifies
      • may result in return of sight in young dogs
    • morgagnian
      • lens nucleus sinks ventrally in liquified cortex
      • all cortical material has been resorbed leaving behind nucleus
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14
Q

Incipient cataract

A
  • early focal opacity of lens
  • appearance
    • punctate
    • linear “spoke-like”
    • vacuoles
  • vision usually not affected
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15
Q

Immature cataract

A
  • Opacity is more expansive than incipient
  • reduced transparency
  • some tapedal reflection remaines
  • decreased vision
  • optimum time to surgically remove
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16
Q

Mature cataract

A
  • Lens totally opaque
  • No tapedal reflection present
  • Eye functionally blind
  • Fundus cannot be examined ophthalmoscopically
17
Q

Hypermature cataract

A
  • Cataract begins to liquefy
  • Wrinkles in anterior lens capsule are visible
  • Crystals
    • glistening particles
    • often present in anterior cortex
  • Lens resorption
  • Morgagnian cataract: sandwich bag with milk and marble
  • Possible sequelae
    • return of vision
    • uveitis
    • retinal detachments
18
Q

Lens-induced uveitis

LIU

A
  • inflammation or uveitis
    • due to reaction to lens antigens in aqueous humor
  • CS
    • flare
      • inc protein
    • miosis
    • hypotony
    • dark ‘muddy’ iris
    • hyperemic episcleral blood vessels
  • LIU must be treated before cataract removal
19
Q

Etiology cataracts in dogs

A
  • inheritance
  • congenital
  • diabetic
    • hexokinase saturated by glucose
    • glucose enters sorbitol pathway
    • converted to sorbitol by aldose reductase
20
Q

Diabetic cataracts

dogs

A
  • form with new lens fibers at equator
    • equatorial vacuoles
    • water clefting (sutures separate)
21
Q

Diabetic cataracts in cats

A
  • not as frequent in cats
    • lower aldose reductase activity than dogs
  • progress more slowly
22
Q

Cataracts in cats

test question

A
  • most common cause
    • secondary to uveitis
  • Other causes
    • trauma
    • gluacoma
    • lens lux
23
Q

Cataracts in horses

test question

A
  • most common cause
    • Equine Recurrent Uveitis (ERU)
    • 41% ERU cases develop cataracts
24
Q

Cataract TX

Medical

A
  • No effective medical therapy yet
    • Kinostat
      • on market Sept 2016 or Dec
      • inhibits aldose reductase in lens
      • TID
      • great for small equatorial cataracts
25
Q

Cataract SX

A
  • phacoemulsification and IOL placement
  • surgical case selection
    1. cataracts with visual impairment
    2. retina must be functional
      • R/O retinal detachment
    3. LIU controlled by corticosteroids and/or NSAIDS
    4. KCS, keratitis, glaucoma must be controlled
    5. patient in general good health, amenable to intensive handling
    6. Owner compliant and can afford tx
    7. Counsel owners about older dogs with
      • cognitive dysfunction
      • senility
      • motor deficits
      • behavior issues
26
Q

Cataract removal procedure

phaco

A
  • phacoemulsification and aspiration
    1. A small corneal incision is made
    2. Circular portion of anterior lens capsule removed
    3. High frequency ultrasonic tip
      • breaks up
      • aspirates cataract
      • infuses fluid to maintain formed eye
27
Q

Post op cataract surgery

IOLs

A
  • hyperoptic post op (Farsighted)
    • artificial lens implant can improve vision
      • 41D (IOL)
  • Pseudophakic
    • animal with an IOL implant
  • Aphakic
    • animal with no lens
    • still visual
  • IOLs available for cats and horses
    • Not routinely used
28
Q

Postop complications of phace and IOLs

A
  • Corneal ulceration
  • anterior uveitis
  • corneal edema
  • suture line dehiscence
  • endothelial decompensation
  • ocular hypertension
  • intraocular fibrin formation
  • acute endophthalmitis
  • hypopyon
  • hyphema
  • IOL lux

*success is about 90-95%

29
Q

Displaced lenses

A
  • lens lux: all zonules torn
    • anterior lux
    • posterior lux
  • Subluxation: some zonules torn
    • partial displacement
30
Q

Etiology of lens luxations

A
  • Primary
    • zonular defects
    • common in terriers
    • autosomal recessive trait
      • commercial testing available
    • Occurs between 2 and 6 years of age
  • Secondary
    • glaucoma
    • anterior uveitis
    • intumescent cataract
    • intraocular tumors
31
Q

Lens lux

CS

A
  • Aphakic crescent
    • pathopneumonic
  • Iridodonesis
    • Movement/shaking of iris
  • Vitreous fibrils floating through pupil into anterior chamber
  • Posterior lux
    • Deep anterior chamber and flat iris
  • Anterior lens lux
    • shallow anterior chamber
    • corneal edema
  • Glaucoma
    • chicken or the egg….
32
Q

Management of lens lux

A
  • Lens sublux
    • monitor and midical tx
    • aggressive tx contraindicated
    • Control secondary issue
      • miotics
      • IOP control
  • Posterior lens lux
    • medical therapy
    • aggressive tx contraindicated
    • causes less damage than anterior lux
  • Anterior lens lux
    • medical therapy and monitoring
    • Intracapsular lens extraction (ICLE)
    • Phacoemulsification w/ capsular tension rings
33
Q

Sulcus Intraocular lens fixation for anterior lens luxation

A
  • Sulcus IOL after anterior lens lux removal
  • Lens sutured in place
34
Q

Multiple punctate pigment foci

A
  • AKA
    • pigment nest
  • located on central anterior lens capsule
  • remnant of pupillary membrane
  • common incidental finding
    • doesn’t usually impair vision
  • No correction