Dyslipidemias

Question 1

Type I Hyperlipoproteinemia

Answer 1

Hypertriglyceridemia
Eruptive Xanthomas
Deficiency of LPL, ApoC-II
Reduced LDL and HDL levels
No inc risk CAD

Question 2

Type II Hyperlipoproteinemia

Answer 2

Tendinous, Tuberoeruptive, Tuberous, Plane (xanthelasma, intertrig, web spaces)
LDL receptor defect, decreased LDL clearance
Defective apo B-100
Inc degradation of LDL receptor bc mutation in PCSK9
Athlerosclerosis of Cor Arts

Question 3

Type III Hyperlipoproteinemia

Answer 3

Apo E abnormalitity
Hypercholesterol, hypertriglyceride
Tuberoeruptive, tuberous, plane (palmar creases), Tendinous atheroscler of periph and CAD

Question 4

Type IV Hyperlipoproteinemia

Answer 4

Elevated production of VLDL
Eruptive Xanthomas
Assoc with Type 2 DM, Obesity, alcohol

Question 5

Type V Hyperlipoproteinemia

Answer 5

Elevated chylomicrons and VLDLs
Decreased LDL and HDL. HyperTG
Eruptive Xanthomas, Assoc with Diabetes

Question 6

Familial LPL deficiency, Familial hyperchylomicronemia

Answer 6

Type I ApoCII and LPL def

Question 7

Familial hyperchol or familal def apoB-100

Answer 7

LDL receptor def

Type II

Question 8

Familial dysbetalipoproteinemia, ApoE def

Answer 8

Type III

Question 9

Endogenous familial HyperTG

Answer 9

Type IV–DM2, etoh, obesity. Eruptive

Question 10

Eruptive Xanthomas

Answer 10

Type I, IV, V

Question 11

Tendinous, Tuberous, Plane

Answer 11

Type II-Plane intertrig, web spaces, xanthelasma

TYpe III–Plane palmar crease