DIF patterns

Question 1

Bullous pemphigoid

Answer 1

n-serrated pattern

linear C3 in 95% and linear IgG4 in 80%

Question 2

Chronic Bullous disease of Childhood

Answer 2

LInear IgA

Question 3

Cicatricial Pemphigoid

Answer 3

LInear C3/IgG, fibrinogen

Occ IgM and IgA in 90%

Question 4

During’s disease

Answer 4

DH

Granular IgA>C3 in dermal papillae

Question 5

Drug induced pemphigus

Answer 5

90% intercellular

Question 6

EBA

Answer 6

u serrated pattern
Linear IgG
(sometimes IgM, IgA, C3, fibrinogen)

Question 7

Herpes Gestastionis

Answer 7

Linear C3, occaisional IgG

Question 8

IgA pemphigus (Intraepidermal type)

Answer 8

100% intercellular IgA

Question 9

IgA pemphigus (subcorneal pustular type)

Answer 9

100% intercellular IgA

Question 10

Paraneoplastic pemphigus

Answer 10

IgG and C3 intercellular and linear/granular at DEJ

Question 11

Pemphigus Erythematosus

Answer 11

LInear IgG at DEJ and intercellular IgG4 in upper layers

Question 12

Pemphigus foliaceous

Answer 12

Intercellular IgG4, usually upper layers

Question 13

Pemphigus vulgaris

Answer 13

Intercellular IgG4>C3, more in lower epi

Question 14

Porphyria Cutanea Tarda

Answer 14

Linear IgG, IgM, IgA and C3, fibrinogen at BM and around vessels

Question 15

Bullous lichen planus

Answer 15

IgM and C3 in colloid bodies

Question 16

Bullous Lupus Erythematous

Answer 16

Linear IgG, IgM, IgA, C3, fibrinogen

Question 17

Coma blister

Answer 17

negative