Antibodies

Question 1

C1q

Answer 1

Severe lupus, urticarial vasculitis

Question 2

dsDNA

Answer 2

High levels with SLE

Low levels with RA, Hashimotos, Graves, Waldenstroms, MCT, SSc, liver disease, SjS

Question 3

Histone

Answer 3

Drug induced LE

Question 4

Phospholipid

Answer 4

Primary APA, 50% SLE,
Drugs: cocaine, interferon, procainamide, hydralazine, phenothiazines, quinine, phenytoid
syphilis, TB, mono, leprosy, CMV, HIV, HCV

Question 5

rRNP

Answer 5

CNS disease witih LE

Question 6

Sm

Answer 6

Most specific antibody for LE

Question 7

ssDNA

Answer 7

Low diagnostic value

SLE in DLE patients, LINEAR MORPHEA IN KIDS

Question 8

U1RNP

Answer 8

MCTD, SLE

Question 9

SRP

Answer 9

Fulminant DM with cardiac involvement

Question 10

Mi-2

Answer 10

Good prognosis; skin only

Question 11

Jo-1

Answer 11

Interstitial lung, anti-synthetase syn, MECHANICS HANDS

Question 12

155kd/Se

Answer 12

Amyopathic DM; cancer

Question 13

Fodrin

Answer 13

Sjogrens

Question 14

SS-B

Answer 14

Sjogrens

Question 15

SSA (Ro)

Answer 15

Annular erythema of Sjogrens
Neonatal lupus
SCLE

Question 16

Centromere

Answer 16

CREST

Question 17

Fibrillin-1

Answer 17

Localized SSc

Question 18

Scl-70 (anti-topoisomerase I)

Answer 18

Diffuse SSc; scleroderma

Question 19

cANCA

Answer 19

Wegners–target proteinase 3

Question 20

pANCA

Answer 20

Microangiopathic vasculitis–target myeloperoxidase

Question 21

Peripheral pattern

Answer 21

target DNA

SLE

Question 22

Homogenous pattern

Answer 22

target DNA and histones

SLE

Question 23

Nucleolar pattern

Answer 23

target RNA

SLE and SSc

Question 24

Centromere pattern

Answer 24

target kinetochore

CREST

Question 25

Speckled pattern

Answer 25

target ribonucleoproteins

MCTD, SLE, SSc, SjS

Question 26

AntiKu

Answer 26

Sclerodermatomyositis