Dyretest - sygdomsmodeller

Question 1

Open field

Answer 1

To test emotionality of rodents, the open field test (OFT) is a commonly used qualitative and quantitative measure of general locomotor activity and willingness to explore in rodents

Areal opdelt i cirkler eller i to kvadrater (inder og yder)

Test compound administrated 30 min. pre test (s.c. 10 ml/kg)
15 min. test
Significant dose-depended increase of time spend in center-zone
No differences in frequency in center-zone
No differences in total distance moved => no hypo / hyper activity

Question 2

Sucrose / saccharin Preference Test

Answer 2

de stressede mus har REDUCERET trang til sukker ift kontrolmus

Question 3

Progressive Ratio for avolition

Answer 3

antal tryk for at få en foder-pellet… 1-1, 2-2, 3-2, 5-3 osv.. demotiverende

Question 4

Porsolt forced swimming test

Answer 4

Test: 6 minutes trial

Read-out: Immobility for the last 3 minutes

Result: % inhibition vs veh.- group

Højere dosis af antidepressivt -> kæmper længere inden de stopper med at svømme

Question 5

Tail suspension test

Answer 5

Test sessions are 6 minutes long
Read-out: Immobility
Results: % inhibition vs veh.- group

Højere dosis af antidepressivt -> kæmper længere inden de stopper med at svømme

Question 6

Marble burrying

Answer 6

Measures a possible anxiety-related behaviour of the mouse.
Procedure: 30 minutes test

Marbles there has been moved or buried are counted