Drugs used in Neurology Flashcards
what is selegiline used for, how does it act?
PD
MAO-B
Inhibition of MAO + potentiates dopamine.
Reduces end dose akinesia.
What is amantadine used for?
how does it act?
PD
Potentiates dopamine - re-uptake inhibitor
MOA of levodopa
pro drug = converted in substantia nigra
for how long is levodopa effective?
at 8 years 50% patientes have deteriorated to pre treatement levels.
name 5 dopamine receptor agonists
bromocriptine,
cabergoline,
pergollide,
pramiprexole,
ropinerole
what are the main benefits of dopamine receptor agonist over levodopa?
less dyskinesia but have more neuropsychiatric adverse effects.
common side effects of levodopa
cardiac arrhythmias
dyskinesia
N + V
postural hypotension
psychosis
somnolescence (sleepy)
what is the MOA of Orlistat?
inhibits pancreatic lipase
when is sumatriptan contraindicated?
Hemiplegic migraine
What are the common side effects of Sumatriptan?
chest pain - vasospasm
drowsiness / fatigue
flushing
what are the main side effects of chlorpromazine?
Agranulocytosis
Purple pigmentation
Dystonia / oculogyric crisis
NMS
Photosensitivity
VT
at what level does one expect to see toxicity in patient using lithium?
> 2mmol/L
when is lithium toxicitiy most likely?
renal impairment / electrolyte imbalance
presence of nephrotoxic drugs
common s/e of lithium
fine tremor
loose stool
nausea
polydipsia
polyuria
weigth gain
rare s/e of lithium
goitre
hypothyroidism
psoriasis
