Drugs used in Endocrinology + Gastro

Question 1

what is the MOA of Carbimazole?

Answer 1

inhibits thyroid hormone production from the amino acid tyrosine

Question 2

what is the onset time for carbimazole

Answer 2

6 weeks to lower blood levels

Question 3

most common side effect of Carbimazole

Answer 3

agranulocytosis
(monitor for sore throat)

Question 4

Carbimazole: important knowledge for pregnant women

Answer 4

crosses placenta

given in low does fetal hypothyroidism may not occur

Question 5

What are the two pure 5-amino salicylic acid molecules ?

Answer 5

Mesalazine
Olsalazinew

Question 6

what is the indication for 5-ASA drugs?

Answer 6

UC
- they suppress local inflammation at colon

Question 7

common side effects of 5 - ASA drugs?

Answer 7

Nausea, abdo pain, headache.
can worsen colitis

Question 8

Rare side effects of 5-ASA drugs

Answer 8

reversible pancreatitis
intersititial nephritis

Question 9

How does Sulfasalazine differ to the other 5-ASA drgs?

Answer 9

contains sulphonamide

used in UC + RA

Question 10

Common side effect of Sulfasalazine

Answer 10

GI upset - most common

Oligospermia
Orange bodily fluids
SJS
Agranulocytosis
Nephrotic syndrome