Drugs Unit 1

Question 1

Antagonizes VAT

Answer 1

Vesamicol

Question 2

Antagonizes Choline Transporter

Answer 2

Hemicholinium

Question 3

Adds pores to the membrane, resulting in excess calcium influx and explosive release of Acetylcholine,

Answer 3

Black Widow Spider Venom

Question 4

3 Classes of Ach Esterase inhibitor and the associated drugs

Answer 4

1- Short acting ionic– Edrophonium, Ambenonium
2-Short-med acting covalent– Neostygmine, Physostygmine, Pyridostygmine
3- Long acting covalent– Insectisides- Isofluorophate, malathion, parathion
-Nerve gases (soman, tabun, sarin)
-Echothiophate

Question 5

Muscarinic cholinergic Receptor Agonists (4, 2 specific for M, 1 specific for N)

Answer 5

1-Acetylcholine– Not used in clinic
2-Bethanechol– Muscarinic specific
3-Pilocarpine– Muscarinic specific
4-Nicotine– Nicotinic Specific

Question 6

Muscarinic cholinergic Receptor Antagonists (4)

Answer 6

1-Atropine
2-Scopalamine
3-Benztropine
4-Propantholine

Question 7

Antagonizes Tyrosine Hydroxylase (turns Tyrosine into DOPA)

Answer 7

alpha-methyl-Tyrosine (Metyrosine)

Question 8

Antagonizes L-Aromatic Amino Acid Decarboxylase (Turns DOPA into Dopamine) (2)

Answer 8

1- Carbidopa

2- alpha-methyl-DOPA

Question 9

Blocks the release of catecholamines (2)

Answer 9

1- Bretylium

2- Guanethide

Question 10

Block the Norepinephrine Transporter and prevent reuptake (2)

Answer 10

1- Cocaine

2- Tricyclic Antidepressants

Question 11

Reverse transporter by competing with norepinephrine (2)

Answer 11

1-Amphetamines

2-Pseudoephedrine

Question 12

Antagonizes Dopamine Beta-hydroylase

Answer 12

Disulfiram

Question 13

Inhibits storage of catecholamines

Answer 13

Reserpine

Question 14

Non-Selective alpha adrenergic antagonists (2)

Answer 14

1-Phentolamine

2-Phenoxybenzamine

Question 15

Selective alpha-1 adrenergic antagonists (3)

Answer 15

1-Prazosin
2-Terazosin
3-Doxazosin

Question 16

Nonselective beta adrenergic antagonist

Answer 16

Propranolol

Question 17

Selective beta-1 adrenergic antagonists (2)

Answer 17

1-Metoprolol

2-Atenolol

Question 18

Inhibits VSSCs

Answer 18

Lidocaine

Question 19

Cleaves Synaptobrevin in the peripheral excitatory nerve terminals

Answer 19

Botulinum Toxin

Question 20

Inhibits VSCCs

Answer 20

Iamotrigine

Question 21

Inhibitor of the Ryanodine receptor (and alternate use)

Answer 21

Dantrolene Sodium (also used in Malignant Hyperthermia)

Question 22

Non-depolarizing competitive (reversible) nicotinic cholinergic receptor blockers (and the prototype one no longer used)

Answer 22

1-Atacurium
2-Rocuronium
(Tubocurarine or Curare)

Question 23

Depolarizing competitive (reversible) nicotinic cholinergic receptor blocker

Answer 23

Succyinylcholine

Question 24

What makes Curare derivatives useful?

Answer 24

They competitively inhibit the receptor, which means you can reverse their effects by pushing AchE-is.

Also, their effect allows direct stimulation by electricity or potassium to still work.

Question 25

What is the antidote for irreversible inhibitors of acetylcholinesterase?

Answer 25

Pralidoxime

Question 26

Diazapam

Answer 26

Anti-Convulsant

Question 27

Alpha-1-selective adrenergic agonists

Answer 27

Phenylephrine

Question 28

Alpha-2-selective adrenergic agonists

Answer 28

Clonidine

Question 29

Non selective beta adrenergic

Answer 29

Isoproterenol

Question 30

Beta-2-selective adrenergic agonists

Answer 30

Albuterol

Question 31

Indirected adrenergic agonist for NE

Answer 31

Pseudoephedrine

Question 32

Nonselective Adrenergic antagonist

Answer 32

Labetalol