Drugs to treat IBD

Question 1

What do aminosalicylates do?

Answer 1

Rely on anaerobic bacteria in the colon to divide enzymatically the ado-bond that joins the two moieties together (something that can be split)

Question 2

What is mesalazine, what does it treat and what does it do?

Answer 2

Aminosalicylate

• treats mild-to-moderate UC
• modulates inflammatory cytokine secretion + inhibits leukotrienes, prostaglandins that are responsible for the expression of pro-inflammatory molecules.

Question 3

What are 2 widely used antibiotics for flare ups of IBD?

Answer 3

Metronidazole + ciproflaxin

Long-term use not recommended