Drugs that weaken cell walls that aren't penicillin

Question 1

Monobactam

Answer 1

Aztreonam
G- ONLY, COVERS PSEUDOMONAS. Narrow spectrum/reserved
ADR: neutropenia in children and increased AST/ALT

Question 2

Carbapenams

Answer 2

EXTREMELY broad spectrum, all cover anaerobes
Restricted for infectious disease consult or a positive culture
DIME
Doripenem, Imipenem, Meropenem: MSSA to pseudomonas
Ertapenem: No pseudomonas, great OP infusion drug for MDR G-

Question 3

Cephalosporins

Answer 3

Most widely used group of antibiotics

Often given in hospitals to document tolerance

Question 4

1st gen Cephalosporins

Answer 4

Cephalexin (Keflex) and Cefazolin (Ancef)
Surgical prophylaxis, skin/soft tissue infections
Keflex for UTIs
Ancef can do MSSA

Question 5

2nd Generation Cephalosporin

Answer 5

Cefuroxime

G+ and G- infections, a lot of respiratory bacterial infections

Question 6

3rd Gen Cephalosporins

Answer 6

Ceftriaxone (Rocephin)
VERY common for community acquired pneumonia, UTI, G-, and meningitis
Most prescribed antibiotic in hospitals

Ceftazidme: psuedomonal coverage, used in neonates and dialysis

Cefdinir: G- and G+ and respiratory infections

Question 7

4th Gen Cephalosporin

Answer 7

Cefepime: Pseudomonal coverage and more G- species

Question 8

5th Gen Cephalosporin

Answer 8

Ceftaroline: rarely used, the only cephalosporin that covers MRSA

Question 9

Glycopeptides

Answer 9

G+ primarily used in MRSA, patients with penicillin allergies, C diff
Primary agent is Vancomycin

Question 10

Vancomycin

Answer 10

Vanco
Used in cellulitis cases, G+ bacteremia, pneumonia, covers staph and strep until cultures are resulted
ADR: Nephrotoxic, Red Man Syndrome from rapid infusion causing a histamine release, thrombocytopenia

Question 11

Fosfomycin

Answer 11

Uncomplicated UTI
Psuedomonas, GNRs, VRE
Only effective in the bladder
Well tolerated