Drugs that act on Sympathetic NS Flashcards
direct acting adrenergic receptor agonists
mimic NE:
- increase hr
- vasoconstriction increase BP
- broncholidation
- relax intestinal sm
- dilation of iris
- glycogen>glucose
- triglycerides>fatty acids
catecholamine agonists
- NE
- E - card arrest, asthma, shock
- DOPAMINE
- ISOPROTERENOL- cardiac arrest
weakly selective adrenergic agonists
ISOPROTERENOL
- bradycardia
- heart block
- bronchospasm during GE
- hypovolemic shock
- congestive heart failure
- cardaic arrest
IV/cardiac injection
// anxiety, blurred vision, sweating, hypertension
a1 selective agonist
PHENYLEPHRINE - relaxation of sm (except: sm in GI tract)
-nasal decongestant
// hypertension refelx bradycardia
a2 agonists
CLONIDINE - partial agonist in sm
activates autoreceptors = inhibit NE release
-hypertension
-hot flashes
-glaucoma
prvent migrane/headaches
//orthostation hypotension rebound hypertension
B1 agonist
DOBUTAMINE - cardiac tissue = increase heart rate
- reestablish normal HR following heart attack
// cardiac arrhythmias
B2 agonist
ALBUTEROL - relax sm, dilation of blood vessels, inhibit histamine release
- treat asthma,
- pre-mature labour
//tachycardia cardiac arrhythmias
indirect-acting sympathomimetics 1
enhance action of endogenous/exogenous activators of adrenergic receptors
AMPHETAMINES - stimulate NE release
- decreases NE uptake
- displacement of NE from vesicles
- leakage of NE from cytoplasm > synapse
indirect-acting sympathomimetics 2
uptake blockers
cocaine
indirect-acting sympathomimetics 3
metabolic inhibitors
MAO
Catecholamine-O-methyl transferase inhibitors
SYMPATHOLYTICS
- tyrosine-hydroxylase inhibitors - a-METHYLTYROSINE
- storage inhibitors
- release inhibitors
- antagonists
a1 antagonist
PRAZOSIN
- treat hypertension
- urinary blockage
// same as non-selective a antagonists but less potent
b1 antagonist
METOPROLOL
-treat angina/hypertension
//bradycardia
b3 receptor function
- lipid breakdown
2. heat generation
