CNS Flashcards
what happens if you block synthesis/storage of NT
what happens if you block reuptake/inactivation of NT
inhibit the effects of NT
enhance the effects of NT
explain neural networks in the CNS
you can have many neurons interacting with each other
some NT has inhibitory effects in CNS
dales principle
single neuron = only release 1 NT
cotransmission in PNS
single neuron = release up to 2 NT
cotransmission CNS
single neuron = release of multiple (up to 4) NT
what is the problem with cotransmission in CNS
NT all acting on different downstream neurons
= inhibit the release of one NT => others may still have action = enhance/suppress effects
tonic activity in CNS
some CNS neurons undergo spontaneous excitation due to constant inward leakage of Na+ ions
= cells subject to direct actions of inhibitory NT/drugs(regulate)
(don’t require constant A.P)
contrast CNS tonic activity in PNS
AP > NT release: rapid release/uptake + require another AP for another response
how do you get epileptic seizures
how do you treat
mutation in Na+ channels = more leaky
enhance/mimic activity of I NT
describe 4 effects of repeated stimulation in CNS
habituation
facilitation
plasticity
habituation
repetitive stimulation of a neuron = generates smaller response - caused by inactivation of VG ion channels
(more drug for same response, high conc = off target effects: activate other receptors with lower affinity for drug)
facilitation
repetitive stimulation of a nerve raises the Ca2+ level = reducing the threshold stimulus required for response
plasticity (LTP)
repetitive stimulation of a neuron generates a larger response (degree of response continues to increase even when there are long delays between each stimulus
CNS excitatory NT
glutamate
asparate
ACh
CNS inhibitory NT
GABA (brain)
glycine (brain stem + spinal cord)
NE
