DRUGS: SKIN & SOFT TISSUE INFECTIONS Flashcards

1
Q

Drugs used for Cellulitis?

A
  • Cephalexin
  • Clindamycin
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2
Q

Drugs used for Decubitus Ulcers?

A
  • Ciprofloxacin
  • Clindamycin
  • Vancomycin
  • Piperacillin-Tazobactam
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3
Q

Cephalexin
• MOA
• Adverse effects

A

MOA: Inhibits bacterial wall synthesis

ADVERSE EFFECTS:
More common - Rash, diarrhoea, thrombophlebitis
Less common - SJS, severe hypersensitivity

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4
Q

Cephalexin
• Pharm class
• Indication

A

Pharm Class:
Beta-lactam Abx (1st gen Cephalosporin)

Indication:
Cellulitis

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5
Q

Clindamycin:
• Pharm Class
• Indication

A

Pharm Class:
Lincosamide Protein Synthesis Inhibitor

Indication:
Cellulitis & Decubitus Ulcer

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6
Q

Clindamycin
• MOA
• Adverse Effects

A

MOA:
Inhibits protein synthesis

ADVERSE EFFECTS:
- Nausea, vomiting
- Diarrhoea, constipation
- Headache

Severe:
- Myopathy
- Pseudomembrane colitis
- Superinfection
- Anaphylaxis

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7
Q

Ciprofloxacin
• Pharm Class
• Indication

A

Pharm Class:
2nd Gen Fluoroquinolones

Indication:
Decubitus Ulcer

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8
Q

Ciprofloxacin
• MOA
• Adverse effects

A

MOA:
Inhibits DNA synthesis

ADVERSE EFFECTS:
- Nausea, vomiting, headache, pain at inj. site

Severe:
- Tendon rupture, seizures, photosensitivity
- Pseudomembrane colitis, peripheral neuropathy
- Hepatotoxicity

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9
Q

Which drug is not suitable for elderly with tendonitis & athletes with ruptured tendon?

A

Ciprofloxacin

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10
Q

Vancomycin
• MOA
• Adverse effects

A

MOA:
Inhibits bacterial cell wall synthesis and transglycosylation

ADVERSE EFFECTS:
- Ototoxicity
- Red Man’s Syndrome
- Anaphylaxis
- Nephrotoxicity
- Superinfection
- Nausea, vomiting

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11
Q

Piperacillin-Tazobactam (Pip-Taz)
• MOA
• Adverse effects

A

MOA:
Inhibits bacterial cell wall synthesis & transpeptidation

ADVERSE EFFECTS:
More common - Rash, diarrhoea, thrombophlebitis
Less common - SJS, severe hypersensitivity

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12
Q

Vancomycin
• Pharm Class
• Indication

A

Pharm Class:
Non-Betalactam; Glycopeptide

Indication:
Decubitus Ulcer

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13
Q

Piperacillin-Tazobactam
• Pharm Class
• Indication

A

Pharm Class:
Beta-lactam Abx with Oxapenams
Aminopenicillins

Indication:
Decubitus Ulcer

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14
Q

Which drug is reserved for MRSA?

A

Vancomycin

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15
Q

Which drugs are Broad Spectrum?

A
  • Cephalexin
  • Clindamycin
  • Ciprofloxacin
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16
Q

Which drug has an Extended Spectrum?

A

Piperacillin-Tazobactam