drugs: bone infections

Question 1

Alendronate, Risedronate MOA, use

Answer 1

MOA: inhibits bone breakdown (structural analog, natural substance)

use: FRACTURES
- plateau effect after 1st year

Question 2

Alendronate, Risedronate S/E

Answer 2

Nausea, dyspepsia,
diarrhoea, bone and
back pain

Question 3

Denosumab use, MOA

Answer 3

use: FRACTURES (targeted for postmenopausal, high risk of fractures, bone tumors)

MOA: inhibits RANK, responsible for bone reabsorption

Question 4

Denosumab S/E

Answer 4

fatigue
asthma
hypophosphatemia
nausea
hypercholesterolemia
MSK pain
hypocalcemia

Question 5

Teriparatide use, MOA

Answer 5

use: FRACTURES (high risk of bone fractures, but req. daily SC)

MOA: like endogenous PTH to increase bone formation

Question 6

Teriparatide S/E

Answer 6

dizziness, vertigo
depression, insomnia
rhinitis, cough
leg cramps, arthralgia
nausea