Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Genetics & Neoplasia > Drugs Randomized > Flashcards

Drugs Randomized Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

Gemcitabine

A

Class: Anti metabolite

Mechanism: 1. Inhibits polymerase and end chain terminator

CCNS/CCS: CCS

Administered: IV

Resistance: ???

Side effects: Bone marrow depression + GI tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Flutamide

A

Class: Androgen inhibitor

Mechanism: 1. Inhibits the binding of androgens to their receptors 2. It is taken with radiation when treating prostate cancer

CCNS/CCS: CCNS

Administered: Oral

Resistance: ???

ide effects: Nausea, hot flushes and Transient hepatic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Bleomycin

A

Class: Anti tumor antibody

Mechanism: 1. Releases free radicals

CCNS/CCS: CCS

Administered: IV

Resistance: MDR

Side effects: Pulmonary toxicity and fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Docataxel

A

Class: Microtubule poisons

Mechanism: 1. Excessive stabilization of microtubules

CCNS/CCS: CCS

Administered: in cremaphore nanoparticles that causes severe inflammatory response

Resistance: MDR

Side effects: Neuropathy and bone marrow depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Doxorubicin

A

Class: Anti tumor antibody

Mechanism: 1. Binds with DNA, does not form adducts 2. Releases free radicals when close to DNA

CCNS/CCS: CCNS

Administered: IV

Resistance: MDR

Side effects: Alopecia and cardiotoxicity, drug Dexrazoxane is given to control cardiotoxicity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Daunorubicin

A

Class: Anti tumor antibody

Mechanism: 1. Binds with DNA, does not form adducts 2. Releases free radicals when close to DNA

CCNS/CCS: CCNS

Administered: IV

Resistance: MDR

Side effects: Alopecia and cardiotoxicity, drug Dexrazoxane is given to control cardiotoxicity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Methotrextate

A

Class: Anti metabolite

Mechanism: 1. Mimics folic acid. 2. It inhibits formation of bases from DHFR, so no DNA and RNA can be made

CCNS/CCS: CCS

Administered: IV + Orally

Resistance: Decreased concentration of the drug in cancer cells and increase in [DHFR]

Side effects: Bone marrow depression and GI tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Vinblastin

A

Class: Microtubule poisons

Mechanism: 1. Inhibits polymerization 2. Promotes depolymerization

CCNS/CCS: CCS

Administered: IV

Resistance:???

Side effects: Nausea, vomiting, alopecia, bone marrow supression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cisplatin

A

Class: Alkylating agent

Mechanism: Interstrand and intrastrand crosslinks - DNA adducts

CCNS/CCS: CCNS

Administered: IV

Resistance: Apoptosis, MDR, increased DNA repair

Side effects: Severe nausea and vomiting, otatoxicity, peripheral nephrotoxicity, nephrotoxicity is the dose limiting factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

6-Thiopurine

A

Class: Anti metabolite

Mechanism: 1. Purine analog. 2. It inhibits the DNA and RNA synthesis 3. Inactivated by Thiopurine Methyl Reductase

CCNS/CCS: CCS

Administered: Orally

Resistance: Decrease in levels of HPRT and increase in alkaline phosphatase activity.

Side effects: Bone marrow depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Paclitaxel

A

Class: Microtubule poisons

Mechanism: 1. Excessive stabilization of microtubules CCNS/CCS:

CCS

Administered: in cremaphore nanoparticles that causes severe inflammatory response

Resistance: MDR

Side effects: Neuropathy and bone marrow depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anastrazole

A

Class: AI Mechanism: 1. Inhibits the conversion of andrgoens CCNS/CCS: CCNS Administered: Orally Resistance: ??? Side effects: Headache, nausea , fatigue, hot flushes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Lestrozole

A

Class: AI Mechanism: 1. Inhibits the conversion of andrgoens CCNS/CCS: CCNS Administered: Orally Resistance: ??? Side effects: Headache, nausea , fatigue, hot flushes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Tamoxifen

A

Side effects: Fatigue, headache and vaginal bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mecholoroethamine

A

Class: Alkylating agent

Mechanism: Interstrand and intrastrand crosslinks - DNA adducts

CCNS/CCS: CCNS

Administered: IV

Resistance: Apoptosis, MDR, increased DNA repair

Side effects: Nausea, vomiting, myelosuppression (dose limiting factor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Dasatinab

A

Class: Tyrosine kinase inhibitor

Mechanism: 1. Inhibits the tyrosine kinase receptors in BCR/ABL for Chronic Mylogenous Leukemia 2. Inhibits FIT receptor in Gastrointestinal Sarcoma Tumor (GIST)

CCNS/CCS: CCNS

Administered: Orally

Resistance: ???

Side effects: Myelosuppression, edema and hepatotoxicity

17
Q

Imatinab

A

Class: Tyrosine kinase inhibitor Mechanism: 1. Inhibits the tyrosine kinase receptors in BCR/ABL for Chronic Mylogenous Leukemia 2. Inhibits FIT receptor in Gastrointestinal Sarcoma Tumor (GIST) CCNS/CCS: CCNS Administered: Orally Resistance: ??? Side effects: Myelosuppression, edema and hepatotoxicity

18
Q

6-Mecarptopurine

A

Class: Anti metabolite

Mechanism: 1. Purine analog. 2. It inhibits the synthesis of AMP and GMP. 3. Inactivated by Thiopurine Methyl Reductase

CCNS/CCS: CCS

Administered: Orally

Resistance: Decrease in levels of HPRT and increase in alkaline phosphatase activity.

Side effects: Bone marrow depression

19
Q

Gefitinab

A

Class: Tyrosine kinase inhibitor Mechanism: 1. Inhibits EGFR tyrosine kinase 2. For non-small cell lung cancer CCNS/CCS: CCNS Administered: Orally Resistance: ??? Side effects: Fever and dyspnea

20
Q

Irinotaxen

A

Class: Topoisomerase inhibitor

Mechanism: SN-38 is its active form, converted by esterase

CCNS/CCS: CCS

Administered: IV

Resistance: Inactivated by glucouridination by UGT1A1 and reduction in esterase levels

Side effects: Nausea, vomiting and Diarrhea (dose limiting)

21
Q

5-Fluorouracil

A

Class: Anti metabolite

Mechanism: 1. Inhibits the synthesis of thymidine 2. Inhibits thimidylate synthase enzyme

CCNS/CCS: CCS

Administered: IV

Resistance: Increase in [Thimidylate Synthase] and overexpression of DPD

Side effects: Bone marrow depression + GI tract

22
Q

Cyclophosphamide

A

Class: Alkylating agent Mechanism: Interstrand and intrastrand crosslinks - DNA adducts CCNS/CCS: CCNS Administered: IV + Oral - it is broken down in lover to its active form Resistance: Apoptosis, MDR, increased DNA repair Side effects: Nausea, vomiting, sterile hemorrhagic cystitus, alopecia - mesna is administer to help with bladder problems and the patient is given forced hydration

23
Q

Trastuzumab

A

Cardiomyopathy

24
Q

Vincristine

A

Class: Microtubule poisons Mechanism: 1. Inhibits polymerization 2. Promotes depolymerization CCNS/CCS: CCS Administered: IV Resistance:??? Side effects: Peripheral neurotoxicity and less bone marrow suppression than vinblastin

Genetics & Neoplasia (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions