Drugs of Angina Flashcards
to learn the drugs
What are the 5 drugs used to treat angina
Nitrates GTN Beta Blockers Calcium channel antagonists Potassium channel antagonists I(f) channel antagonist
when is GTN taken
before exercise
What could Beta Blockers cause
bronchospasm
What does a potassium channel agonist cause (drug wanted result)
vasodilation
What are the 3 effects of aspirin
analgesic (pain killer) , anti-inflammatory and fever
What is the mechanism of aspirin
INactivates COX enzyme which produces prostaglandin and thromboxane
No Prostaglandins = anti-inflammatory effects
No thromboxane = No Thromboxane A2 which is produced by activated platelets and causes more platelets to be produced , also it inhibits platelet aggregation
What is the COX enzyme associated with
produces prostaglandin and thromboxane
What is Bisoprolol in terms of affinity and receptors
Has a high affinity for B1 receptors (adrenergic) (sympathetic)
What is the mechanism of Bisoprolol
Blocks B1 adrenergic receptors
Decreases adrenergic stimulation (sympathetic)
Slows Heart rate
What drug is used against thrombosis
Ticagrelor
What is the mechanism of action of Ticagrelor
Platelet aggregation inhibitor as it blocks the ADP (adenosine diphosphate) receptor on platelets
What type of drug is Atorvastatin
A fucking statin
What is the mechanism of Atorvastatin
It is a competitive inhibitor of HMG-CoA reductase enzyme
HMG-CoA is produced in the liver and catalyses hepatitc cholesterol biosynthesis
Thus cholesterol synthesis is reduced
Expression of LDL receptor increases on hepatocytes
Thus increased uptake of LDL on the liver this blood LDL decreases
What are the 3 effects of aspirin
Pain killer, Antipyretic, Anti-inflammatory
What is the mechanism of asprin
COX forms prostaglandins and thromboxane - No prostaglandins = anti-inflammatory effect. No arachidonic acid to Thromboxane A2 = no stimulation of new platelets
