Cardiac Electrophysiology and cardiac metabolism Flashcards
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What cells make up the SAN
myocytes
Do the myocytes have a resting potential
No it is called the pacemaker potential
What does the heart use as a back up in the first few minutes that there is no O2 from aerobic respiration
Phosphocreatine
What happens after phosphocreatine has been used up
aerobic metabolism switches on however it produces lactate
What does the lactic acid do to the heart and where does it build up
reduced ph and accumulates in extracellular space and cytosol
What is a rigor mortis contraction
rigor mortis is the stiffening of the body due to a lack of ATP after death. Only temporary
What is Ischaemia
anoxia (absence of O2) No removal of lactate loss of K+ pumping ext due to ion pumps have no fuel No flow Just bad tings
What does calcium do to the heart
stimulates contraction
What happens if calcium isn’t stored in the right places at low concentrations
it may trigger apoptosis
do the kidneys like low perfusion
“absolutely not”
jodie 2019
What happens if you inhibit fibrinolysis
Prevent fibrin breakdown
What does HDL increase
increase fibrinolysis
What is fibrinolysis
the enzymatic breakdown of the fibrin in blood clots.
what prevents absorption of dietary cholesterol
ezetimibe
What are statins
competitive inhibitors that similar in structure which lowers cholesterol which leads to more ldl receptors which increases the removal of LDL from plasma and increases HDL and lowers triglycerides
