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Pharm Test 3 > Drugs of Abuse > Flashcards

Drugs of Abuse Flashcards

1
Q

Schedule I

A

LSD
Heroin
marijuana

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2
Q

Schedule II

A

Opiates
Amphetamine
Cocaine
Barbituates

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3
Q

Schedule III

A

Codeine+acetaminophen

Anabolic steroids

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4
Q

Schedule IV

A

Benzos

Tramadol

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5
Q

Schedule V

A

OTC cough meds w/ codeine

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6
Q

Addiction pathway

A

Mesocorticolimbic pathway, DA

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7
Q

Types of tolerance

A
  • Cellular (receptor regulation)

* Metabolic (elimination)

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8
Q

Physiological dependence = susbstance use disorder?

A

NO

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9
Q

Alcohol

Mech

A

Up Gaba, down glutamate

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10
Q

Alcohol withdrawal syndrome

Tx

A

Mild: clonidine/propranolol

Severe: Diazepam

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11
Q

Alcohol relapse

Tx

A

Aversion = Disulfiram

Anti-craving =

  • Naltrexone
  • acamprosate
  • topiramate
  • SSRI
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12
Q

Barbituate withdrawal
(seizures)

tx

A

Phenobarbitol

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13
Q

Benzo high-dose withdrawal (seizure)

Tx

A
  • Phenobarbitol

* long-acting benzo

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14
Q

Methadone pharm advantages over Heroin

A
  • no sharp peaks and valleys

* Methadone withdrawal less

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15
Q

Opioid use disorder

Tx

A
  • Methadone
  • LAAM (levo-alpha-acetyl methadyl)
  • Buprenorphine
  • Naltrexone
  • Clonidine
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16
Q

Nicotine

Tx

A
  • Nicotine Replacement Therapy
    (pharmacokinetics slower than smoking)
    *Bupropion (zyban) = reduce craving, decrease withdrawal
    *Varenicline (chantix) = a4b2 partial ag (less reward, less addict/craving/withdrawal) (black box PSYC)
17
Q

Cannabinoid receptor BLOCKER

A

Rimonabant

withdrawn in europe for PSYC toxic

18
Q

Endogenous cannabinoids

A
  • anandamide

* 2-arachidonoyl glycerol

19
Q

Synthetic THC

A

Dronabinol (marinol Sched 3) = nausea/anorexia in AIDS/chemo

20
Q

Amphetamine

Mech

A

DA + NE release

21
Q

Cocaine

Mech + S.E.

A

DA re-uptake blocker

S.E. = premature labor, developmental abnormalities

22
Q

Stimulant OD

A

Seizures
Stroke (vasoconstricton)
psychosis

23
Q

Stimulant

Reverse tolerance

A

=senstization

UP stroke/arrythmia risk

24
Q

Stimulant withdrawal

A

depression

usually no treatment

25
Q

Stimulant Use disorder

tx

A

related to route (smoking worse)

VERY difficult to treat

26
Q

Stimulant

Preventing relapse

A

Psychotherapy (AA)

Topiramate
Anti-depressants

27
Q

Hallucinogens

Psychedelics : Serotonin-related

A

LSD
Psilocybin
DMT

*Ags = 5HT/DA/Adrenergic

28
Q

Hallucinogens

Psychedellics : DA/Amphetamine-related

A

MDA
MDMA
Mescaline

*Ags= 5HT/DA/Adrergic/ 5HT reuptake inhibit

29
Q

Hallucinogens

Psychedelics: Kappa opioid receptor

A

Salvinorin A

30
Q

Dissociatives

A

PCP

Ketamine

31
Q

Deliriants

A

Scopolamine

Atropine

32
Q

Hallucinagens

Addiction- Tx

A

not addictive

*behavioral/social support

33
Q

Dissociatives (PCP/Ket)

mech

A

general anesthetic

*inhibit NMDA receptors

34
Q

PCP/ketamine

CNS effects

A
  • Analgesia/anesthesia
  • Feelings of detachment from self/environment
  • Hallucinations
  • Delusions

HIGH DOSE: seizure, coma, death

35
Q

PCP/ketamine

Peripheral effects

A
  • Sympathomimetic : UP HR/BP/sweating

* Parasympathomimetic: UP salivation

36
Q

PCP/ketamine

Tx

A

none, counseling

addiction possible

Pharm Test 3 (11 decks)

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