Drugs & liver disease Flashcards
1
Q
What are the potential adverse drugs reactions of NSAID use?
A
- Peptic ulcers
- CV toxicity – worsen heart failure
- HTN
- CHF
- Na+ retention
- Worsen asthma
- Diarrhoea/colitis
- Renal failure
2
Q
What should NSAID’s or COX-inhibitors be co-prescribed with ?
A
- A PPI
3
Q
What adverse drug reaction can diuretics used in the treatment of liver disease cause?
A
- Gout
4
Q
In patients with liver disease why should they be given paracetamol 1g BD rather than QDS ?
A
- Because in liver disease paracetamol has a much longer half-life so this is to avoid overdosing someone
5
Q
Should NSAID’s be avoided in someone with liver disease ?
A
- Yes
6
Q
What is Hy’s rule ?
A
If patient has ALT/AST > 5 x ULN And Bilirubin > 3mg/dl. And absence of raised ALP & no other reason for raised LFT markers e.g. viral hepatitis Then they are at high risk of a fatal drug-induced liver injury
