Drugs in solution

Question 1

What does the partition coefficient (P or log P) measure?

Answer 1

Measures the way a drug distributes itself between two immiscible solvent (e.g. Octagon/water)

Question 2

What does the greater the value of P mean?

Answer 2

The higher the lipophilicity (or lipid solubility) of the solute

Question 3

What does the lipophilicity of a drug influence?

Answer 3

Its bioavailability following oral administration

Question 4

What is the partition coefficient?

Answer 4

Ratio of concentrations of non ionised drug in the two phases of a mixture of two immiscible solvents at equilibrium

Question 5

What is the distribution coefficient (D or log Dora apparent partition coefficient)?

Answer 5

The ration of the sum of the concentrations of all forms of the drug (ionised plus un-ionised) in each of the two phases

Question 6

What is the distribution coefficient (D or log D or apparent partition coefficient)?

Answer 6

The ration of the sum of the concentrations of all forms of the drug (ionised plus un-ionised) in each of the two phases